| Name | LCK |
| ID | P06239 |
| Role | substrate |
| Enzymatic Domains |
SH3 61-121 PROSITE-ProRule
SH2 127-224 PROSITE-ProRule
Protein kinase 245-498 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates | 16461343 | SIGNOR-144341 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 11259588 | SIGNOR-248350 |
| PTPRF | LCK | – | dephosphorylation up-regulates | 12496362 | SIGNOR-96771 | |
| MAPK1 | LCK | Ser59 | EGSNPPAsPLQDNLV | phosphorylation up-regulates activity | 8618896 | SIGNOR-249412 |
| CSK | LCK | Tyr505 | FTATEGQyQPQP | phosphorylation down-regulates | 1639064 | SIGNOR-20371 |
| Gbeta | LCK | – | phosphorylation up-regulates activity | 8618896 | SIGNOR-270074 | |
| PTPRC | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11259588 | SIGNOR-248351 |
| PTPN6 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11294838 | SIGNOR-106604 |
| PRKACA | LCK | Ser42 | TLLIRNGsEVRDPLV | phosphorylation unknown | 8506364 | SIGNOR-249999 |
| LCK | LCK | Tyr394 | RLIEDNEyTAREGAK | phosphorylation up-regulates activity | 2250907 | SIGNOR-81372 |
| MAPK3 | LCK | Ser59 | EGSNPPAsPLQDNLV | phosphorylation up-regulates activity | 8618896 | SIGNOR-249469 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 17719247 | SIGNOR-259933 |
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248836 |
| SYK | LCK | Tyr192 | NLDNGGFyISPRITF | phosphorylation down-regulates activity | 8798764 | SIGNOR-246562 |
| PRKCA | LCK | Ser42 | TLLIRNGsEVRDPLV | phosphorylation unknown | 8506364 | SIGNOR-248936 |
| DUSP22 | LCK | – | dephosphorylation down-regulates activity | 27557500 | SIGNOR-277148 | |
| ERK1/2 | LCK | – | phosphorylation up-regulates activity | 8618896 | SIGNOR-270177 | |
| FYN | LCK | Tyr505 | FTATEGQyQPQP | phosphorylation down-regulates activity | 22043010 | SIGNOR-279986 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-144341 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 11259588 | SIGNOR-248350 |
| MAPK1 | phosphorylation up-regulates → | LCK PSer59 | phosphorylation up-regulates → | LCK | 8618896 | SIGNOR-249412 |
| CSK | phosphorylation up-regulates → | LCK PTyr505 | phosphorylation down-regulates ⊣ | LCK | 1639064 | SIGNOR-20371 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11259588 | SIGNOR-248351 |
| PTPN6 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11294838 | SIGNOR-106604 |
| PRKACA | phosphorylation up-regulates → | LCK PSer42 | phosphorylation down-regulates ⊣ | LCK | 8506364 | SIGNOR-249999 |
| LCK | phosphorylation up-regulates → | LCK PTyr394 | phosphorylation up-regulates → | LCK | 2250907 | SIGNOR-81372 |
| MAPK3 | phosphorylation up-regulates → | LCK PSer59 | phosphorylation up-regulates → | LCK | 8618896 | SIGNOR-249469 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 17719247 | SIGNOR-259933 |
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-248836 |
| SYK | phosphorylation up-regulates → | LCK PTyr192 | phosphorylation down-regulates ⊣ | LCK | 8798764 | SIGNOR-246562 |
| PRKCA | phosphorylation up-regulates → | LCK PSer42 | phosphorylation down-regulates ⊣ | LCK | 8506364 | SIGNOR-248936 |
| FYN | phosphorylation up-regulates → | LCK PTyr505 | phosphorylation down-regulates ⊣ | LCK | 22043010 | SIGNOR-279986 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN22 | dephosphorylation down-regulates | LCK | SIGNOR-144341 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-248350 |
| PTPRF | dephosphorylation → up-regulates | LCK | SIGNOR-96771 |
| MAPK1 | phosphorylation → up-regulates activity | LCK | SIGNOR-249412 |
| CSK | phosphorylation down-regulates | LCK | SIGNOR-20371 |
| Gbeta | phosphorylation → up-regulates activity | LCK | SIGNOR-270074 |
| PTPRC | dephosphorylation → down-regulates activity | LCK | SIGNOR-248351 |
| PTPN6 | dephosphorylation → down-regulates activity | LCK | SIGNOR-106604 |
| PRKACA | phosphorylation → unknown | LCK | SIGNOR-249999 |
| LCK | phosphorylation → up-regulates activity | LCK | SIGNOR-81372 |
| MAPK3 | phosphorylation → up-regulates activity | LCK | SIGNOR-249469 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-259933 |
| PTPN22 | dephosphorylation → down-regulates activity | LCK | SIGNOR-248836 |
| SYK | phosphorylation → down-regulates activity | LCK | SIGNOR-246562 |
| PRKCA | phosphorylation → unknown | LCK | SIGNOR-248936 |
| DUSP22 | dephosphorylation → down-regulates activity | LCK | SIGNOR-277148 |
| ERK1/2 | phosphorylation → up-regulates activity | LCK | SIGNOR-270177 |
| FYN | phosphorylation → down-regulates activity | LCK | SIGNOR-279986 |