| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | LCK | Tyr505 | FTATEGQyQPQP | phosphorylation down-regulates activity | 22043010 | SIGNOR-279986 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 17719247 | SIGNOR-259933 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 11259588 | SIGNOR-248350 |
| CSK | LCK | Tyr505 | FTATEGQyQPQP | phosphorylation down-regulates | 1639064 | SIGNOR-20371 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | LCK PTyr505 | phosphorylation down-regulates ⊣ | LCK | 22043010 | SIGNOR-279986 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 17719247 | SIGNOR-259933 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 11259588 | SIGNOR-248350 |
| CSK | phosphorylation up-regulates → | LCK PTyr505 | phosphorylation down-regulates ⊣ | LCK | 1639064 | SIGNOR-20371 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → down-regulates activity | LCK | SIGNOR-279986 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-259933 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-248350 |
| CSK | phosphorylation down-regulates | LCK | SIGNOR-20371 |
