| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11259588 | SIGNOR-248351 |
| LCK | LCK | Tyr394 | RLIEDNEyTAREGAK | phosphorylation up-regulates activity | 2250907 | SIGNOR-81372 |
| PTPN6 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11294838 | SIGNOR-106604 |
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248836 |
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates | 16461343 | SIGNOR-144341 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11259588 | SIGNOR-248351 |
| LCK | phosphorylation up-regulates → | LCK PTyr394 | phosphorylation up-regulates → | LCK | 2250907 | SIGNOR-81372 |
| PTPN6 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11294838 | SIGNOR-106604 |
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-248836 |
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-144341 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRC | dephosphorylation → down-regulates activity | LCK | SIGNOR-248351 |
| LCK | phosphorylation → up-regulates activity | LCK | SIGNOR-81372 |
| PTPN6 | dephosphorylation → down-regulates activity | LCK | SIGNOR-106604 |
| PTPN22 | dephosphorylation → down-regulates activity | LCK | SIGNOR-248836 |
| PTPN22 | dephosphorylation down-regulates | LCK | SIGNOR-144341 |
