| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-216674 |
| CDK1 | NPM1 | Ser70 | EAMNYEGsPIKVTLA | phosphorylation unknown | 19933706 | SIGNOR-161801 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 14670079 | SIGNOR-216690 |
| PLK1 | NPM1 | Ser4 | sMDMDMSP | phosphorylation up-regulates | 15190079 | SIGNOR-125666 |
| CDK2 | NPM1 | Ser70 | EAMNYEGsPIKVTLA | phosphorylation unknown | 19933706 | SIGNOR-161805 |
| DUSP3 | NPM1 | – | dephosphorylation down-regulates activity | 33777934 | SIGNOR-277005 | |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 14670079 | SIGNOR-120330 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-216662 |
| PLK2 | NPM1 | Ser4 | sMDMDMSP | phosphorylation up-regulates | 15190079 | SIGNOR-125720 |
| CDK1 | NPM1 | Thr237 | KQEKTPKtPKGPSSV | phosphorylation down-regulates activity | 14670079 | SIGNOR-120334 |
| AKT1 | NPM1 | Ser48 | QLSLRTVsLGAGAKD | phosphorylation down-regulates activity | 25071014 | SIGNOR-276667 |
| CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-235725 |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-235530 |
| ATM | NPM1 | – | phosphorylation up-regulates activity | 21499441 | SIGNOR-280182 | |
| CHUK | NPM1 | Ser125 | AVEEDAEsEDEEEED | phosphorylation up-regulates activity | 24290756 | SIGNOR-279405 |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-89597 |
| CyclinB/CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-216745 |
| CDK1 | NPM1 | Thr237 | KQEKTPKtPKGPSSV | phosphorylation down-regulates activity | 12058066 | SIGNOR-89601 |
| CyclinB/CDK1 | NPM1 | Thr237 | KQEKTPKtPKGPSSV | phosphorylation down-regulates activity | 12058066 | SIGNOR-216749 |
| CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-89609 |
| CDK1 | NPM1 | Thr199 | VKKSIRDtPAKNAQK | phosphorylation down-regulates activity | 12058066 | SIGNOR-89605 |
| CyclinE/CDK2 | NPM1 | Thr199 | VKKSIRDtPAKNAQK | phosphorylation down-regulates activity | 11278991 | SIGNOR-250744 |
| CyclinB/CDK1 | NPM1 | Thr199 | VKKSIRDtPAKNAQK | phosphorylation down-regulates activity | 12058066 | SIGNOR-216845 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-216674 |
| CDK1 | phosphorylation up-regulates → | NPM1 PSer70 | phosphorylation down-regulates ⊣ | NPM1 | 19933706 | SIGNOR-161801 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-216690 |
| PLK1 | phosphorylation up-regulates → | NPM1 PSer4 | phosphorylation up-regulates → | NPM1 | 15190079 | SIGNOR-125666 |
| CDK2 | phosphorylation up-regulates → | NPM1 PSer70 | phosphorylation down-regulates ⊣ | NPM1 | 19933706 | SIGNOR-161805 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-120330 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216662 |
| PLK2 | phosphorylation up-regulates → | NPM1 PSer4 | phosphorylation up-regulates → | NPM1 | 15190079 | SIGNOR-125720 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr237 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-120334 |
| AKT1 | phosphorylation up-regulates → | NPM1 PSer48 | phosphorylation down-regulates ⊣ | NPM1 | 25071014 | SIGNOR-276667 |
| CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-235725 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-235530 |
| CHUK | phosphorylation up-regulates → | NPM1 PSer125 | phosphorylation up-regulates → | NPM1 | 24290756 | SIGNOR-279405 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89597 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216745 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr237 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89601 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NPM1 PThr237 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216749 |
| CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89609 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr199 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89605 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr199 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-250744 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NPM1 PThr199 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216845 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216674 |
| CDK1 | phosphorylation → unknown | NPM1 | SIGNOR-161801 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216690 |
| PLK1 | phosphorylation → up-regulates | NPM1 | SIGNOR-125666 |
| CDK2 | phosphorylation → unknown | NPM1 | SIGNOR-161805 |
| DUSP3 | dephosphorylation → down-regulates activity | NPM1 | SIGNOR-277005 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-120330 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216662 |
| PLK2 | phosphorylation → up-regulates | NPM1 | SIGNOR-125720 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-120334 |
| AKT1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-276667 |
| CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-235725 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-235530 |
| ATM | phosphorylation → up-regulates activity | NPM1 | SIGNOR-280182 |
| CHUK | phosphorylation → up-regulates activity | NPM1 | SIGNOR-279405 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89597 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216745 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89601 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216749 |
| CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89609 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89605 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-250744 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216845 |
