| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | NPM1 | Ser70 | EAMNYEGsPIKVTLA | phosphorylation unknown | 19933706 | SIGNOR-161801 |
| CDK2 | NPM1 | Ser70 | EAMNYEGsPIKVTLA | phosphorylation unknown | 19933706 | SIGNOR-161805 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | NPM1 PSer70 | phosphorylation down-regulates ⊣ | NPM1 | 19933706 | SIGNOR-161801 |
| CDK2 | phosphorylation up-regulates → | NPM1 PSer70 | phosphorylation down-regulates ⊣ | NPM1 | 19933706 | SIGNOR-161805 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → unknown | NPM1 | SIGNOR-161801 |
| CDK2 | phosphorylation → unknown | NPM1 | SIGNOR-161805 |
