Entity Details

Name CyclinB/CDK1_Thr199
ID P06748
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK1NPM1Thr199VKKSIRDtPAKNAQKphosphorylation
down-regulates activity		12058066SIGNOR-89605
CyclinE/CDK2NPM1Thr199VKKSIRDtPAKNAQKphosphorylation
down-regulates activity		11278991SIGNOR-250744
CyclinB/CDK1NPM1Thr199VKKSIRDtPAKNAQKphosphorylation
down-regulates activity		12058066SIGNOR-216845
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK1phosphorylation
up-regulates
→
NPM1
PThr199		phosphorylation
down-regulates
⊣		NPM112058066SIGNOR-89605
CyclinE/CDK2phosphorylation
up-regulates
→
NPM1
PThr199		phosphorylation
down-regulates
⊣		NPM111278991SIGNOR-250744
CyclinB/CDK1phosphorylation
up-regulates
→
NPM1
PThr199		phosphorylation
down-regulates
⊣		NPM112058066SIGNOR-216845
Regulator Mechanism/Effect Target SIGNOR-ID
CDK1phosphorylation
→
down-regulates activity 		NPM1SIGNOR-89605
CyclinE/CDK2phosphorylation
→
down-regulates activity 		NPM1SIGNOR-250744
CyclinB/CDK1phosphorylation
→
down-regulates activity 		NPM1SIGNOR-216845