| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-216674 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 14670079 | SIGNOR-216690 |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 14670079 | SIGNOR-120330 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-216662 |
| CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-235725 |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-235530 |
| CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-89597 |
| CyclinB/CDK1 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-216745 |
| CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-89609 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-216674 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-216690 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-120330 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216662 |
| CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-235725 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-235530 |
| CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89597 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216745 |
| CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-89609 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216674 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216690 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-120330 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216662 |
| CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-235725 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-235530 |
| CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89597 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216745 |
| CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-89609 |
