Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
RPS6KA5	TH	Ser40	GQGAPGPsLTGSPWP	phosphorylation up-regulates	12421349	SIGNOR-95491
CDK5	TH	–		phosphorylation up-regulates activity	15471880	SIGNOR-279022
MAPKAPK5	TH	Ser19 View in OncoXplorer	KGFRRAVsELDAKQA	phosphorylation up-regulates	12421349	SIGNOR-95479
MAPKAPK2	TH	Ser19 View in OncoXplorer	KGFRRAVsELDAKQA	phosphorylation up-regulates activity	11359875	SIGNOR-250149
RPS6KA3	TH	Ser40	GQGAPGPsLTGSPWP	phosphorylation up-regulates	12421349	SIGNOR-95483
CAMK2A	TH	Ser19 View in OncoXplorer	KGFRRAVsELDAKQA	phosphorylation up-regulates	1680128	SIGNOR-20912
MAPKAPK2	TH	Ser40	GQGAPGPsLTGSPWP	phosphorylation up-regulates activity	11359875	SIGNOR-250150
MAPK3	TH	Ser62	SYTPTPRsPRFIGRR	phosphorylation up-regulates	7901013	SIGNOR-34678
MAPK1	TH	Ser62	SYTPTPRsPRFIGRR	phosphorylation up-regulates	7901013	SIGNOR-34674
RPS6KA3	TH	Ser40	GQGAPGPsLTGSPWP	phosphorylation up-regulates	7901013	SIGNOR-34682
PRKACA	TH	Ser40	GQGAPGPsLTGSPWP	phosphorylation up-regulates activity	11359875	SIGNOR-250061
RPS6KA3	TH	Ser71 View in OncoXplorer	RFIGRRQsLIEDARK	phosphorylation up-regulates	12421349	SIGNOR-95487
Gbeta	TH	–		phosphorylation up-regulates	7901013	SIGNOR-270055
CAMK2G	TH	Ser19 View in OncoXplorer	KGFRRAVsELDAKQA	phosphorylation up-regulates activity	1680128	SIGNOR-250709
ERK1/2	TH	–		phosphorylation up-regulates	7901013	SIGNOR-270167
RPS6KA3	TH	Ser71 View in OncoXplorer	RFIGRRQsLIEDARK	phosphorylation up-regulates	7901013	SIGNOR-34686

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
RPS6KA5	phosphorylation up-regulates →	TH PSer40	phosphorylation up-regulates →	TH	12421349	SIGNOR-95491
MAPKAPK5	phosphorylation up-regulates →	TH PSer19	phosphorylation up-regulates →	TH	12421349	SIGNOR-95479
MAPKAPK2	phosphorylation up-regulates →	TH PSer19	phosphorylation up-regulates →	TH	11359875	SIGNOR-250149
RPS6KA3	phosphorylation up-regulates →	TH PSer40	phosphorylation up-regulates →	TH	12421349	SIGNOR-95483
CAMK2A	phosphorylation up-regulates →	TH PSer19	phosphorylation up-regulates →	TH	1680128	SIGNOR-20912
MAPKAPK2	phosphorylation up-regulates →	TH PSer40	phosphorylation up-regulates →	TH	11359875	SIGNOR-250150
MAPK3	phosphorylation up-regulates →	TH PSer62	phosphorylation up-regulates →	TH	7901013	SIGNOR-34678
MAPK1	phosphorylation up-regulates →	TH PSer62	phosphorylation up-regulates →	TH	7901013	SIGNOR-34674
RPS6KA3	phosphorylation up-regulates →	TH PSer40	phosphorylation up-regulates →	TH	7901013	SIGNOR-34682
PRKACA	phosphorylation up-regulates →	TH PSer40	phosphorylation up-regulates →	TH	11359875	SIGNOR-250061
RPS6KA3	phosphorylation up-regulates →	TH PSer71	phosphorylation up-regulates →	TH	12421349	SIGNOR-95487
CAMK2G	phosphorylation up-regulates →	TH PSer19	phosphorylation up-regulates →	TH	1680128	SIGNOR-250709
RPS6KA3	phosphorylation up-regulates →	TH PSer71	phosphorylation up-regulates →	TH	7901013	SIGNOR-34686

Regulator	Mechanism/Effect	Target	SIGNOR-ID
RPS6KA5	phosphorylation → up-regulates	TH	SIGNOR-95491
CDK5	phosphorylation → up-regulates activity	TH	SIGNOR-279022
MAPKAPK5	phosphorylation → up-regulates	TH	SIGNOR-95479
MAPKAPK2	phosphorylation → up-regulates activity	TH	SIGNOR-250149
RPS6KA3	phosphorylation → up-regulates	TH	SIGNOR-95483
CAMK2A	phosphorylation → up-regulates	TH	SIGNOR-20912
MAPKAPK2	phosphorylation → up-regulates activity	TH	SIGNOR-250150
MAPK3	phosphorylation → up-regulates	TH	SIGNOR-34678
MAPK1	phosphorylation → up-regulates	TH	SIGNOR-34674
RPS6KA3	phosphorylation → up-regulates	TH	SIGNOR-34682
PRKACA	phosphorylation → up-regulates activity	TH	SIGNOR-250061
RPS6KA3	phosphorylation → up-regulates	TH	SIGNOR-95487
Gbeta	phosphorylation → up-regulates	TH	SIGNOR-270055
CAMK2G	phosphorylation → up-regulates activity	TH	SIGNOR-250709
ERK1/2	phosphorylation → up-regulates	TH	SIGNOR-270167
RPS6KA3	phosphorylation → up-regulates	TH	SIGNOR-34686