| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA3 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates | 12421349 | SIGNOR-95483 |
| MAPKAPK2 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates activity | 11359875 | SIGNOR-250150 |
| RPS6KA3 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates | 7901013 | SIGNOR-34682 |
| RPS6KA5 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates | 12421349 | SIGNOR-95491 |
| PRKACA | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates activity | 11359875 | SIGNOR-250061 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA3 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 12421349 | SIGNOR-95483 |
| MAPKAPK2 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 11359875 | SIGNOR-250150 |
| RPS6KA3 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 7901013 | SIGNOR-34682 |
| RPS6KA5 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 12421349 | SIGNOR-95491 |
| PRKACA | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 11359875 | SIGNOR-250061 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA3 | phosphorylation → up-regulates | TH | SIGNOR-95483 |
| MAPKAPK2 | phosphorylation → up-regulates activity | TH | SIGNOR-250150 |
| RPS6KA3 | phosphorylation → up-regulates | TH | SIGNOR-34682 |
| RPS6KA5 | phosphorylation → up-regulates | TH | SIGNOR-95491 |
| PRKACA | phosphorylation → up-regulates activity | TH | SIGNOR-250061 |
