| Name | FES |
| ID | P07332 |
| Role | kinase |
| Enzymatic Domains |
F-BAR 1-260 PROSITE-ProRule
SH2 460-549 PROSITE-ProRule
Protein kinase 561-822 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | FES | Tyr713 | REEADGVyAASGGLR | phosphorylation up-regulates | 8663427 | SIGNOR-42655 |
| FES | FES | Tyr811 | RPSFSTIyQELQSIR | phosphorylation up-regulates | 8663427 | SIGNOR-42659 |
| FES | FES | Tyr139 | Y-->K | phosphorylation up-regulates activity | 18775312 | SIGNOR-277898 |
| FES | BCR | Tyr246 | SCGVDGDyEDAELNP | phosphorylation down-regulates | 8955135 | SIGNOR-45330 |
| FES | BCR | Tyr279 | PPLEYQPyQSIYVGG | phosphorylation down-regulates | 8955135 | SIGNOR-45334 |
| FES | BCR | Tyr283 | YQPYQSIyVGGMMEG | phosphorylation down-regulates | 8955135 | SIGNOR-45343 |
| FES | BCR | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation down-regulates activity | 8955135 | SIGNOR-251136 |
| FES | BCR | Tyr246 | SCGVDGDyEDAELNP | phosphorylation down-regulates activity | 8955135 | SIGNOR-251137 |
| FES | PECAM1 | Tyr690 | PLNSDVQyTEVQVSS | phosphorylation up-regulates activity | 12972546 | SIGNOR-262867 |
| FES | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 12972546 | SIGNOR-262868 |
| FES | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 15003822 | SIGNOR-278937 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | phosphorylation up-regulates → | FES PTyr713 | phosphorylation up-regulates → | FES | 8663427 | SIGNOR-42655 |
| FES | phosphorylation up-regulates → | FES PTyr811 | phosphorylation up-regulates → | FES | 8663427 | SIGNOR-42659 |
| FES | phosphorylation up-regulates → | FES PTyr139 | phosphorylation up-regulates → | FES | 18775312 | SIGNOR-277898 |
| FES | phosphorylation up-regulates → | BCR PTyr246 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45330 |
| FES | phosphorylation up-regulates → | BCR PTyr279 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45334 |
| FES | phosphorylation up-regulates → | BCR PTyr283 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45343 |
| FES | phosphorylation up-regulates → | BCR PTyr177 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-251136 |
| FES | phosphorylation up-regulates → | BCR PTyr246 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-251137 |
| FES | phosphorylation up-regulates → | PECAM1 PTyr690 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262867 |
| FES | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262868 |
| FES | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 15003822 | SIGNOR-278937 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FES | phosphorylation → up-regulates | FES | SIGNOR-42655 |
| FES | phosphorylation → up-regulates | FES | SIGNOR-42659 |
| FES | phosphorylation → up-regulates activity | FES | SIGNOR-277898 |
| FES | phosphorylation down-regulates | BCR | SIGNOR-45330 |
| FES | phosphorylation down-regulates | BCR | SIGNOR-45334 |
| FES | phosphorylation down-regulates | BCR | SIGNOR-45343 |
| FES | phosphorylation → down-regulates activity | BCR | SIGNOR-251136 |
| FES | phosphorylation → down-regulates activity | BCR | SIGNOR-251137 |
| FES | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262867 |
| FES | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262868 |
| FES | phosphorylation → up-regulates activity | STAT3 | SIGNOR-278937 |