| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | ADRB2 | Ser345 | ELLCLRRsSLKAYGN | phosphorylation down-regulates activity | 1848190 | SIGNOR-248857 |
| AKT | ADRB2 | Ser345 | ELLCLRRsSLKAYGN | phosphorylation down-regulates | 11809767 | SIGNOR-114466 |
| AKT1 | ADRB2 | Ser345 | ELLCLRRsSLKAYGN | phosphorylation down-regulates | 11809767 | SIGNOR-252469 |
| GRK5 | ADRB2 | Ser411 | RNCSTNDsLL | phosphorylation unknown | 8662852 | SIGNOR-251198 |
| AKT | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates | 11809767 | SIGNOR-114470 |
| PRKCD | ADRB2 | Ser261 | TGHGLRRsSKFCLKE | phosphorylation down-regulates activity | 1848190 | SIGNOR-248854 |
| INSR | ADRB2 | Tyr132 | CVIAVDRyFAITSPF | phosphorylation down-regulates activity | 8557631 | SIGNOR-251299 |
| PRKCD | ADRB2 | Ser262 | GHGLRRSsKFCLKEH | phosphorylation down-regulates activity | 1848190 | SIGNOR-248855 |
| AKT1 | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates | 11809767 | SIGNOR-252470 |
| GRK5 | ADRB2 | Ser401 | VPSDNIDsQGRNCST | phosphorylation unknown | 8662852 | SIGNOR-251196 |
| INSR | ADRB2 | Tyr350 | RRSSLKAyGNGYSSN | phosphorylation down-regulates activity | 8557631 | SIGNOR-251301 |
| INSR | ADRB2 | Tyr141 | AITSPFKyQSLLTKN | phosphorylation down-regulates activity | 8557631 | SIGNOR-251300 |
| GRK5 | ADRB2 | Thr393 | DFVGHQGtVPSDNID | phosphorylation unknown | 8662852 | SIGNOR-251200 |
| INSR | ADRB2 | Tyr354 | LKAYGNGySSNGNTG | phosphorylation down-regulates activity | 8557631 | SIGNOR-251302 |
| PRKCD | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates activity | 1848190 | SIGNOR-248856 |
| GRK5 | ADRB2 | Ser396 | GHQGTVPsDNIDSQG | phosphorylation unknown | 8662852 | SIGNOR-251195 |
| GRK5 | ADRB2 | Thr384 | LCEDLPGtEDFVGHQ | phosphorylation unknown | 8662852 | SIGNOR-251199 |
| GRK5 | ADRB2 | Ser407 | DSQGRNCsTNDSLL | phosphorylation unknown | 8662852 | SIGNOR-251197 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | ADRB2 PSer345 | phosphorylation down-regulates ⊣ | ADRB2 | 1848190 | SIGNOR-248857 |
| AKT | phosphorylation up-regulates → | ADRB2 PSer345 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-114466 |
| AKT1 | phosphorylation up-regulates → | ADRB2 PSer345 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-252469 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer411 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251198 |
| AKT | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-114470 |
| PRKCD | phosphorylation up-regulates → | ADRB2 PSer261 | phosphorylation down-regulates ⊣ | ADRB2 | 1848190 | SIGNOR-248854 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr132 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251299 |
| PRKCD | phosphorylation up-regulates → | ADRB2 PSer262 | phosphorylation down-regulates ⊣ | ADRB2 | 1848190 | SIGNOR-248855 |
| AKT1 | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-252470 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer401 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251196 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr350 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251301 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr141 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251300 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PThr393 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251200 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr354 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251302 |
| PRKCD | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 1848190 | SIGNOR-248856 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer396 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251195 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PThr384 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251199 |
| GRK5 | phosphorylation up-regulates → | ADRB2 PSer407 | phosphorylation down-regulates ⊣ | ADRB2 | 8662852 | SIGNOR-251197 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCD | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-248857 |
| AKT | phosphorylation down-regulates | ADRB2 | SIGNOR-114466 |
| AKT1 | phosphorylation down-regulates | ADRB2 | SIGNOR-252469 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251198 |
| AKT | phosphorylation down-regulates | ADRB2 | SIGNOR-114470 |
| PRKCD | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-248854 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251299 |
| PRKCD | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-248855 |
| AKT1 | phosphorylation down-regulates | ADRB2 | SIGNOR-252470 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251196 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251301 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251300 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251200 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251302 |
| PRKCD | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-248856 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251195 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251199 |
| GRK5 | phosphorylation → unknown | ADRB2 | SIGNOR-251197 |
