| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates | 11809767 | SIGNOR-114470 |
| AKT1 | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates | 11809767 | SIGNOR-252470 |
| PRKCD | ADRB2 | Ser346 | LLCLRRSsLKAYGNG | phosphorylation down-regulates activity | 1848190 | SIGNOR-248856 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-114470 |
| AKT1 | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 11809767 | SIGNOR-252470 |
| PRKCD | phosphorylation up-regulates → | ADRB2 PSer346 | phosphorylation down-regulates ⊣ | ADRB2 | 1848190 | SIGNOR-248856 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation down-regulates | ADRB2 | SIGNOR-114470 |
| AKT1 | phosphorylation down-regulates | ADRB2 | SIGNOR-252470 |
| PRKCD | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-248856 |
