Entity Details

Name CD3E
ID P07766
Role substrate
Enzymatic Domains
Ig-like 32-112
ITAM 178-205
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LCKCD3ETyr199RKGQRDLySGLNQRRphosphorylation
up-regulates activity		11855827SIGNOR-251369
LCKCD3E–phosphorylation
up-regulates activity		2470098SIGNOR-259930
LCKCD3ETyr188PPVPNPDyEPIRKGQphosphorylation
up-regulates activity		11855827SIGNOR-251368
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LCKphosphorylation
up-regulates
→
CD3E
PTyr199		phosphorylation
up-regulates
→		CD3E11855827SIGNOR-251369
LCKphosphorylation
up-regulates
→
CD3E
PTyr188		phosphorylation
up-regulates
→		CD3E11855827SIGNOR-251368
Regulator Mechanism/Effect Target SIGNOR-ID
LCKphosphorylation
→
up-regulates activity 		CD3ESIGNOR-251369
LCKphosphorylation
→
up-regulates activity 		CD3ESIGNOR-259930
LCKphosphorylation
→
up-regulates activity 		CD3ESIGNOR-251368