| Name | EPRS1 |
| ID | P07814 |
| Role | substrate |
| Enzymatic Domains |
WHEP-TRS 1 749-805 PROSITE-ProRule
WHEP-TRS 2 822-878 PROSITE-ProRule
WHEP-TRS 3 900-956 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | EPRS1 | Ser886 | LSQSSDSsPTRNSEP | phosphorylation down-regulates | 21220307 | SIGNOR-171138 |
| CDK5 | EPRS1 | Ser886 | LSQSSDSsPTRNSEP | phosphorylation down-regulates | 19647514 | SIGNOR-187383 |
| RPS6KB1 | EPRS1 | Ser999 | NQGGGLSsSGAGEGQ | phosphorylation up-regulates activity | 28178239 | SIGNOR-279483 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | EPRS1 PSer886 | phosphorylation down-regulates ⊣ | EPRS1 | 21220307 | SIGNOR-171138 |
| CDK5 | phosphorylation up-regulates → | EPRS1 PSer886 | phosphorylation down-regulates ⊣ | EPRS1 | 19647514 | SIGNOR-187383 |
| RPS6KB1 | phosphorylation up-regulates → | EPRS1 PSer999 | phosphorylation up-regulates → | EPRS1 | 28178239 | SIGNOR-279483 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5 | phosphorylation down-regulates | EPRS1 | SIGNOR-171138 |
| CDK5 | phosphorylation down-regulates | EPRS1 | SIGNOR-187383 |
| RPS6KB1 | phosphorylation → up-regulates activity | EPRS1 | SIGNOR-279483 |