| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 15537644 | SIGNOR-248471 |
| PTPRA | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 15537644 | SIGNOR-248436 |
| PTPRC | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 10415030 | SIGNOR-248353 |
| LYN | LYN | Tyr397 | RVIEDNEyTAREGAK | phosphorylation up-regulates activity | 8530369 | SIGNOR-251402 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 15537644 | SIGNOR-248471 |
| PTPRA | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 15537644 | SIGNOR-248436 |
| PTPRC | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 10415030 | SIGNOR-248353 |
| LYN | phosphorylation up-regulates → | LYN PTyr397 | phosphorylation up-regulates → | LYN | 8530369 | SIGNOR-251402 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | LYN | SIGNOR-248471 |
| PTPRA | dephosphorylation → down-regulates activity | LYN | SIGNOR-248436 |
| PTPRC | dephosphorylation → down-regulates activity | LYN | SIGNOR-248353 |
| LYN | phosphorylation → up-regulates activity | LYN | SIGNOR-251402 |
