| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | LYN | Tyr508 | YTATEGQyQQQP | dephosphorylation down-regulates activity | 10415030 | SIGNOR-248354 |
| MATK | LYN | Tyr508 | YTATEGQyQQQP | phosphorylation down-regulates activity | 9171348 | SIGNOR-250177 |
| CSK | LYN | Tyr508 | YTATEGQyQQQP | phosphorylation down-regulates | 15626731 | SIGNOR-132912 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | dephosphorylation down-regulates ⊣ | LYN PTyr508 | dephosphorylation up-regulates → | LYN | 10415030 | SIGNOR-248354 |
| MATK | phosphorylation up-regulates → | LYN PTyr508 | phosphorylation down-regulates ⊣ | LYN | 9171348 | SIGNOR-250177 |
| CSK | phosphorylation up-regulates → | LYN PTyr508 | phosphorylation down-regulates ⊣ | LYN | 15626731 | SIGNOR-132912 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRC | dephosphorylation → down-regulates activity | LYN | SIGNOR-248354 |
| MATK | phosphorylation → down-regulates activity | LYN | SIGNOR-250177 |
| CSK | phosphorylation down-regulates | LYN | SIGNOR-132912 |
