Entity Details

Name FH
ID P07954
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKDCFHThr236IKIGRTHtQDAVPLTphosphorylation
up-regulates activity		26237645SIGNOR-266349
p38FHThr90
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GVTERMPtPVIKAFGphosphorylation
up-regulates activity		30683654SIGNOR-266316
AMPKFHSer75YGAQTVRsTMNFKIGphosphorylation
up-regulates activity		28628081SIGNOR-266313
PAK4FHSer46PNAARMAsQNSFRIEphosphorylation
down-regulates quantity		30683654SIGNOR-266315
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKDCphosphorylation
up-regulates
→
FH
PThr236		phosphorylation
up-regulates
→		FH26237645SIGNOR-266349
p38phosphorylation
up-regulates
→
FH
PThr90		phosphorylation
up-regulates
→		FH30683654SIGNOR-266316
AMPKphosphorylation
up-regulates
→
FH
PSer75		phosphorylation
up-regulates
→		FH28628081SIGNOR-266313
PAK4phosphorylation
up-regulates
→
FH
PSer46		phosphorylation
down-regulates
⊣		FH30683654SIGNOR-266315
Regulator Mechanism/Effect Target SIGNOR-ID
PRKDCphosphorylation
→
up-regulates activity 		FHSIGNOR-266349
p38phosphorylation
→
up-regulates activity 		FHSIGNOR-266316
AMPKphosphorylation
→
up-regulates activity 		FHSIGNOR-266313
PAK4phosphorylation
→
down-regulates quantity 		FHSIGNOR-266315