| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | GJB1 | Ser233 | NPPSRKGsGFGHRLS | phosphorylation up-regulates activity | 8390988 | SIGNOR-248920 |
| PRKACA | GJB1 | Ser233 | NPPSRKGsGFGHRLS | phosphorylation unknown | 8390988 | SIGNOR-249715 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | GJB1 PSer233 | phosphorylation up-regulates → | GJB1 | 8390988 | SIGNOR-248920 |
| PRKACA | phosphorylation up-regulates → | GJB1 PSer233 | phosphorylation down-regulates ⊣ | GJB1 | 8390988 | SIGNOR-249715 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates activity | GJB1 | SIGNOR-248920 |
| PRKACA | phosphorylation → unknown | GJB1 | SIGNOR-249715 |