| Name | IGF1R |
| ID | P08069 |
| Role | kinase |
| Enzymatic Domains |
Fibronectin type-III 1 491-609 PROSITE-ProRule
Fibronectin type-III 2 610-708 PROSITE-ProRule
Fibronectin type-III 3 735-828 PROSITE-ProRule
Fibronectin type-III 4 834-927 PROSITE-ProRule
Protein kinase 999-1274 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IGF1R | PIK3C2A | – | phosphorylation up-regulates | 7692086 | SIGNOR-32076 | |
| IGF1R | IRS4 | – | phosphorylation up-regulates | 9553137 | SIGNOR-56604 | |
| IGF1R | PDPK1 | Tyr373 | SEDDEDCyGNYDNLL | phosphorylation up-regulates | 20044479 | SIGNOR-236548 |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20044479 | SIGNOR-236544 |
| IGF1R | PDPK1 | Tyr373 | SEDDEDCyGNYDNLL | phosphorylation up-regulates | 20643654 | SIGNOR-166710 |
| IGF1R | PDPK1 | Tyr376 | DEDCYGNyDNLLSQF | phosphorylation up-regulates | 20643654 | SIGNOR-166714 |
| IGF1R | IGF1R | Tyr1165 | RDIYETDyYRKGGKG | phosphorylation up-regulates | 7493944 | SIGNOR-26586 |
| IGF1R | IGF1R | Tyr973 | RLGNGVLyASVNPEY | phosphorylation up-regulates | 7493944 | SIGNOR-246252 |
| IGF1R | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 7493944 | SIGNOR-26582 |
| IGF1R | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 7493944 | SIGNOR-26590 |
| IGF1R | IGF1R | Tyr980 | YASVNPEyFSAADVY | phosphorylation up-regulates activity | 7493944 | SIGNOR-246256 |
| IGF1R | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 8940173 | SIGNOR-246248 |
| IGF1R | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 8940173 | SIGNOR-246244 |
| IGF1R | IGF1R | Tyr1346 | SFDERQPyAHMNGGR | phosphorylation up-regulates activity | 8940173 | SIGNOR-246260 |
| IGF1R | PCNA | Tyr133 | LGIPEQEySCVVKMP | phosphorylation up-regulates activity | 28924044 | SIGNOR-277254 |
| IGF1R | PCNA | Tyr250 | DMGHLKYyLAPKIED | phosphorylation up-regulates activity | 28924044 | SIGNOR-277252 |
| IGF1R | PCNA | Tyr60 | RSEGFDTyRCDRNLA | phosphorylation up-regulates activity | 28924044 | SIGNOR-277253 |
| IGF1R | IRS1 | – | phosphorylation up-regulates | 15829723 | SIGNOR-255104 | |
| IGF1R | IRS1 | Tyr1179 | GLENGLNyIDLDLVK | phosphorylation up-regulates | 17827393 | SIGNOR-157730 |
| IGF1R | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates | 17827393 | SIGNOR-157734 |
| IGF1R | IRS1 | Tyr465 | GEEELSNyICMGGKG | phosphorylation up-regulates | 17827393 | SIGNOR-157738 |
| IGF1R | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates | 17827393 | SIGNOR-157742 |
| IGF1R | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates | 17827393 | SIGNOR-157746 |
| IGF1R | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates | 17827393 | SIGNOR-157750 |
| IGF1R | IRS1 | Tyr941 | EETGTEEyMKMDLGP | phosphorylation up-regulates | 17827393 | SIGNOR-157754 |
| IGF1R | IRS1 | Tyr989 | VPSSRGDyMTMQMSC | phosphorylation up-regulates | 17827393 | SIGNOR-157758 |
| IGF1R | IRS1 | – | phosphorylation up-regulates | 21798082 | SIGNOR-175665 | |
| IGF1R | CRK | Tyr221 | GGPEPGPyAQPSVNT | phosphorylation down-regulates activity | 9480911 | SIGNOR-251273 |
| IGF1R | IRS2 | – | phosphorylation up-regulates | 10471495 | SIGNOR-70477 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr373 | phosphorylation up-regulates → | PDPK1 | 20044479 | SIGNOR-236548 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20044479 | SIGNOR-236544 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr373 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166710 |
| IGF1R | phosphorylation up-regulates → | PDPK1 PTyr376 | phosphorylation up-regulates → | PDPK1 | 20643654 | SIGNOR-166714 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1165 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26586 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr973 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246252 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26582 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26590 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr980 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246256 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246248 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246244 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1346 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246260 |
| IGF1R | phosphorylation up-regulates → | PCNA PTyr133 | phosphorylation up-regulates → | PCNA | 28924044 | SIGNOR-277254 |
| IGF1R | phosphorylation up-regulates → | PCNA PTyr250 | phosphorylation up-regulates → | PCNA | 28924044 | SIGNOR-277252 |
| IGF1R | phosphorylation up-regulates → | PCNA PTyr60 | phosphorylation up-regulates → | PCNA | 28924044 | SIGNOR-277253 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr1179 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157730 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157734 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr465 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157738 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157742 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157746 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157750 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr941 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157754 |
| IGF1R | phosphorylation up-regulates → | IRS1 PTyr989 | phosphorylation up-regulates → | IRS1 | 17827393 | SIGNOR-157758 |
| IGF1R | phosphorylation up-regulates → | CRK PTyr221 | phosphorylation down-regulates ⊣ | CRK | 9480911 | SIGNOR-251273 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IGF1R | phosphorylation → up-regulates | PIK3C2A | SIGNOR-32076 |
| IGF1R | phosphorylation → up-regulates | IRS4 | SIGNOR-56604 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-236548 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-236544 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-166710 |
| IGF1R | phosphorylation → up-regulates | PDPK1 | SIGNOR-166714 |
| IGF1R | phosphorylation → up-regulates | IGF1R | SIGNOR-26586 |
| IGF1R | phosphorylation → up-regulates | IGF1R | SIGNOR-246252 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-26582 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-26590 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246256 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246248 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246244 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246260 |
| IGF1R | phosphorylation → up-regulates activity | PCNA | SIGNOR-277254 |
| IGF1R | phosphorylation → up-regulates activity | PCNA | SIGNOR-277252 |
| IGF1R | phosphorylation → up-regulates activity | PCNA | SIGNOR-277253 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-255104 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157730 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157734 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157738 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157742 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157746 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157750 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157754 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-157758 |
| IGF1R | phosphorylation → up-regulates | IRS1 | SIGNOR-175665 |
| IGF1R | phosphorylation → down-regulates activity | CRK | SIGNOR-251273 |
| IGF1R | phosphorylation → up-regulates | IRS2 | SIGNOR-70477 |