| Name | IGF1R |
| ID | P08069 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 1 491-609 PROSITE-ProRule
Fibronectin type-III 2 610-708 PROSITE-ProRule
Fibronectin type-III 3 735-828 PROSITE-ProRule
Fibronectin type-III 4 834-927 PROSITE-ProRule
Protein kinase 999-1274 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | IGF1R | Tyr1165 | RDIYETDyYRKGGKG | phosphorylation up-regulates | 8940173 | SIGNOR-45126 |
| IGF1R | IGF1R | Tyr980 | YASVNPEyFSAADVY | phosphorylation up-regulates activity | 7493944 | SIGNOR-246256 |
| SRC | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 7493944 | SIGNOR-246272 |
| IGF1R | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 8940173 | SIGNOR-246248 |
| IGF1R | IGF1R | Tyr1165 | RDIYETDyYRKGGKG | phosphorylation up-regulates | 7493944 | SIGNOR-26586 |
| IGF1R | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 7493944 | SIGNOR-26582 |
| SRC | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 7493944 | SIGNOR-246268 |
| IGF1R | IGF1R | Tyr973 | RLGNGVLyASVNPEY | phosphorylation up-regulates | 7493944 | SIGNOR-246252 |
| IGF1R | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 7493944 | SIGNOR-26590 |
| SRC | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates | 8940173 | SIGNOR-45130 |
| IGF1R | IGF1R | Tyr1166 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 8940173 | SIGNOR-246244 |
| GRK6 | IGF1R | Ser1321 | LPLPDRHsGHKAENG | phosphorylation down-regulates quantity by destabilization | 22509025 | SIGNOR-276412 |
| SRC | IGF1R | Tyr1165 | RDIYETDyYRKGGKG | phosphorylation up-regulates | 7493944 | SIGNOR-246264 |
| IGF1R | IGF1R | Tyr1346 | SFDERQPyAHMNGGR | phosphorylation up-regulates activity | 8940173 | SIGNOR-246260 |
| SRC | IGF1R | Tyr973 | RLGNGVLyASVNPEY | phosphorylation up-regulates activity | 8940173 | SIGNOR-247193 |
| PTK2 | IGF1R | – | phosphorylation up-regulates quantity | 19545541 | SIGNOR-279565 | |
| GRK2 | IGF1R | Ser1278 | EPGFREVsFYYSEEN | phosphorylation down-regulates quantity by destabilization | 22509025 | SIGNOR-276413 |
| SRC | IGF1R | Tyr980 | YASVNPEyFSAADVY | phosphorylation up-regulates activity | 8940173 | SIGNOR-247197 |
| PTPN1 | IGF1R | – | dephosphorylation down-regulates activity | 11884589 | SIGNOR-115709 | |
| SRC | IGF1R | Tyr1161 | FGMTRDIyETDYYRK | phosphorylation up-regulates | 8940173 | SIGNOR-45122 |
| SRC | IGF1R | Tyr1346 | SFDERQPyAHMNGGR | phosphorylation up-regulates activity | 7493944 | SIGNOR-246276 |
| MTOR | IGF1R | – | phosphorylation up-regulates activity | 26584640 | SIGNOR-280044 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | IGF1R PTyr1165 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-45126 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr980 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246256 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246272 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246248 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1165 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26586 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26582 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246268 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr973 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246252 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-26590 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-45130 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1166 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246244 |
| GRK6 | phosphorylation up-regulates → | IGF1R PSer1321 | phosphorylation down-regulates ⊣ | IGF1R | 22509025 | SIGNOR-276412 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1165 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246264 |
| IGF1R | phosphorylation up-regulates → | IGF1R PTyr1346 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-246260 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr973 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-247193 |
| GRK2 | phosphorylation up-regulates → | IGF1R PSer1278 | phosphorylation down-regulates ⊣ | IGF1R | 22509025 | SIGNOR-276413 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr980 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-247197 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1161 | phosphorylation up-regulates → | IGF1R | 8940173 | SIGNOR-45122 |
| SRC | phosphorylation up-regulates → | IGF1R PTyr1346 | phosphorylation up-regulates → | IGF1R | 7493944 | SIGNOR-246276 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates | IGF1R | SIGNOR-45126 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246256 |
| SRC | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246272 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246248 |
| IGF1R | phosphorylation → up-regulates | IGF1R | SIGNOR-26586 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-26582 |
| SRC | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246268 |
| IGF1R | phosphorylation → up-regulates | IGF1R | SIGNOR-246252 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-26590 |
| SRC | phosphorylation → up-regulates | IGF1R | SIGNOR-45130 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246244 |
| GRK6 | phosphorylation down-regulates quantity by destabilization | IGF1R | SIGNOR-276412 |
| SRC | phosphorylation → up-regulates | IGF1R | SIGNOR-246264 |
| IGF1R | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246260 |
| SRC | phosphorylation → up-regulates activity | IGF1R | SIGNOR-247193 |
| PTK2 | phosphorylation → up-regulates quantity | IGF1R | SIGNOR-279565 |
| GRK2 | phosphorylation down-regulates quantity by destabilization | IGF1R | SIGNOR-276413 |
| SRC | phosphorylation → up-regulates activity | IGF1R | SIGNOR-247197 |
| PTPN1 | dephosphorylation → down-regulates activity | IGF1R | SIGNOR-115709 |
| SRC | phosphorylation → up-regulates | IGF1R | SIGNOR-45122 |
| SRC | phosphorylation → up-regulates activity | IGF1R | SIGNOR-246276 |
| MTOR | phosphorylation → up-regulates activity | IGF1R | SIGNOR-280044 |