| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | RHO | Ser334 | PLGDDEAsATVSKTE | phosphorylation unknown | 9099669 | SIGNOR-248966 |
| PRKCA | RHO | Ser343 | TVSKTETsQVAPA | phosphorylation unknown | 9099669 | SIGNOR-248968 |
| GRK1 | RHO | Ser338 | DEASATVsKTETSQV | phosphorylation up-regulates activity | 8617805 | SIGNOR-251190 |
| GRK1 | RHO | Ser334 | PLGDDEAsATVSKTE | phosphorylation up-regulates activity | 8617805 | SIGNOR-251189 |
| GRK1 | RHO | Ser343 | TVSKTETsQVAPA | phosphorylation up-regulates activity | 8617805 | SIGNOR-251191 |
| PRKCA | RHO | Thr336 | GDDEASAtVSKTETS | phosphorylation unknown | 9099669 | SIGNOR-248969 |
| PRKCA | RHO | Ser343 | TVSKTETsQVAPA | phosphorylation unknown | 11910029 | SIGNOR-249148 |
| PRKCA | RHO | Ser338 | DEASATVsKTETSQV | phosphorylation unknown | 11910029 | SIGNOR-249147 |
| PRKCA | RHO | Ser338 | DEASATVsKTETSQV | phosphorylation unknown | 9099669 | SIGNOR-248967 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | RHO PSer334 | phosphorylation down-regulates ⊣ | RHO | 9099669 | SIGNOR-248966 |
| PRKCA | phosphorylation up-regulates → | RHO PSer343 | phosphorylation down-regulates ⊣ | RHO | 9099669 | SIGNOR-248968 |
| GRK1 | phosphorylation up-regulates → | RHO PSer338 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251190 |
| GRK1 | phosphorylation up-regulates → | RHO PSer334 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251189 |
| GRK1 | phosphorylation up-regulates → | RHO PSer343 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251191 |
| PRKCA | phosphorylation up-regulates → | RHO PThr336 | phosphorylation down-regulates ⊣ | RHO | 9099669 | SIGNOR-248969 |
| PRKCA | phosphorylation up-regulates → | RHO PSer343 | phosphorylation down-regulates ⊣ | RHO | 11910029 | SIGNOR-249148 |
| PRKCA | phosphorylation up-regulates → | RHO PSer338 | phosphorylation down-regulates ⊣ | RHO | 11910029 | SIGNOR-249147 |
| PRKCA | phosphorylation up-regulates → | RHO PSer338 | phosphorylation down-regulates ⊣ | RHO | 9099669 | SIGNOR-248967 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-248966 |
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-248968 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251190 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251189 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251191 |
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-248969 |
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-249148 |
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-249147 |
| PRKCA | phosphorylation → unknown | RHO | SIGNOR-248967 |
