| Name | ABCB1 |
| ID | P08183 |
| Role | substrate |
| Enzymatic Domains |
ABC transmembrane type-1 1 51-357 PROSITE-ProRule
ABC transporter 1 392-628 PROSITE-ProRule
ABC transmembrane type-1 2 711-1000 PROSITE-ProRule
ABC transporter 2 1035-1273 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | ABCB1 | Ser667 | SSLIRKRsTRRSVRG | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272508 |
| PKC | ABCB1 | Ser667 | SSLIRKRsTRRSVRG | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272513 |
| PIM1 | ABCB1 | Ser683 | QAQDRKLsTKEALDE | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272511 |
| PKC | ABCB1 | Ser671 | RKRSTRRsVRGSQAQ | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272514 |
| PPP5C | ABCB1 | Ser671 | RKRSTRRsVRGSQAQ | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272507 |
| PKC | ABCB1 | Ser661 | SSNDSRSsLIRKRST | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272512 |
| PKA | ABCB1 | Ser671 | RKRSTRRsVRGSQAQ | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272509 |
| PKA | ABCB1 | Ser683 | QAQDRKLsTKEALDE | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272510 |
| PPP5C | ABCB1 | Ser667 | SSLIRKRsTRRSVRG | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272506 |
| PPP5C | ABCB1 | Ser661 | SSNDSRSsLIRKRST | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272505 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer667 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272508 |
| PKC | dephosphorylation down-regulates ⊣ | ABCB1 PSer667 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272513 |
| PIM1 | dephosphorylation down-regulates ⊣ | ABCB1 PSer683 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272511 |
| PKC | dephosphorylation down-regulates ⊣ | ABCB1 PSer671 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272514 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer671 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272507 |
| PKC | dephosphorylation down-regulates ⊣ | ABCB1 PSer661 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272512 |
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer671 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272509 |
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer683 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272510 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer667 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272506 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer661 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272505 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272508 |
| PKC | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272513 |
| PIM1 | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272511 |
| PKC | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272514 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272507 |
| PKC | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272512 |
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272509 |
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272510 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272506 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272505 |