| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | ABCB1 | Ser683 | QAQDRKLsTKEALDE | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272510 |
| PIM1 | ABCB1 | Ser683 | QAQDRKLsTKEALDE | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272511 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | dephosphorylation down-regulates ⊣ | ABCB1 PSer683 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272510 |
| PIM1 | dephosphorylation down-regulates ⊣ | ABCB1 PSer683 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272511 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272510 |
| PIM1 | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272511 |
