| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | ABCB1 | Ser661 | SSNDSRSsLIRKRST | dephosphorylation up-regulates activity | 24333728 | SIGNOR-272512 |
| PPP5C | ABCB1 | Ser661 | SSNDSRSsLIRKRST | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272505 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | dephosphorylation down-regulates ⊣ | ABCB1 PSer661 | dephosphorylation down-regulates ⊣ | ABCB1 | 24333728 | SIGNOR-272512 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer661 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272505 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKC | dephosphorylation → up-regulates activity | ABCB1 | SIGNOR-272512 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272505 |