| Name | NR3C2 |
| ID | P08235 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 726-964 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | NR3C2 | Ser238 | QGTPLTCsPNVENRG | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276112 |
| MAPK1 | NR3C2 | Ser227 | FGSFPVHsPITQGTP | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276103 |
| MAPK1 | NR3C2 | Ser238 | QGTPLTCsPNVENRG | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276101 |
| MAPK3 | NR3C2 | Ser263 | NVGSPLSsPLSSMKS | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276108 |
| MAPK3 | NR3C2 | Ser287 | SVKSPVSsPNNVTLR | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276110 |
| MAPK3 | NR3C2 | Ser196 | EKSPSVCsPLNMTSS | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276102 |
| MAPK1 | NR3C2 | Ser287 | SVKSPVSsPNNVTLR | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276104 |
| MAPK1 | NR3C2 | Ser263 | NVGSPLSsPLSSMKS | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276105 |
| MAPK1 | NR3C2 | Ser361 | TLRDVVPsPDTQEKG | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276109 |
| GRK5 | NR3C2 | – | phosphorylation down-regulates | 32326036 | SIGNOR-278478 | |
| MAPK1 | NR3C2 | Ser196 | EKSPSVCsPLNMTSS | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276107 |
| MAPK3 | NR3C2 | Ser227 | FGSFPVHsPITQGTP | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276111 |
| MAPK3 | NR3C2 | Ser361 | TLRDVVPsPDTQEKG | phosphorylation down-regulates quantity by destabilization | 22798426 | SIGNOR-276106 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer238 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276112 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer227 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276103 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer238 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276101 |
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer263 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276108 |
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer287 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276110 |
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer196 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276102 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer287 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276104 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer263 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276105 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer361 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276109 |
| MAPK1 | phosphorylation up-regulates → | NR3C2 PSer196 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276107 |
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer227 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276111 |
| MAPK3 | phosphorylation up-regulates → | NR3C2 PSer361 | phosphorylation down-regulates ⊣ | NR3C2 | 22798426 | SIGNOR-276106 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276112 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276103 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276101 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276108 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276110 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276102 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276104 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276105 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276109 |
| GRK5 | phosphorylation down-regulates | NR3C2 | SIGNOR-278478 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276107 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276111 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | NR3C2 | SIGNOR-276106 |