| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | PFKM | Ser762 | YEIDLDTsDHAHLEH | phosphorylation down-regulates activity | 27153534 | SIGNOR-274036 |
| ULK1 | PFKM | Ser74 | EATWESVsMMLQLGG | phosphorylation down-regulates activity | 27153534 | SIGNOR-274035 |
| CyclinD3/CDK6 | PFKM | – | phosphorylation down-regulates activity | 28607489 | SIGNOR-276452 | |
| ULK2 | PFKM | Ser762 | YEIDLDTsDHAHLEH | phosphorylation down-regulates activity | 27153534 | SIGNOR-274044 |
| ULK2 | PFKM | Ser74 | EATWESVsMMLQLGG | phosphorylation down-regulates activity | 27153534 | SIGNOR-274043 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | phosphorylation up-regulates → | PFKM PSer762 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274036 |
| ULK1 | phosphorylation up-regulates → | PFKM PSer74 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274035 |
| ULK2 | phosphorylation up-regulates → | PFKM PSer762 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274044 |
| ULK2 | phosphorylation up-regulates → | PFKM PSer74 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274043 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ULK1 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274036 |
| ULK1 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274035 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PFKM | SIGNOR-276452 |
| ULK2 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274044 |
| ULK2 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274043 |
