| Name | PTPRC |
| ID | P08575 |
| Role | phosphatase |
| Enzymatic Domains |
Fibronectin type-III 1 391-483 PROSITE-ProRule
Fibronectin type-III 2 484-576 PROSITE-ProRule
Tyrosine-protein phosphatase 1 653-912 PROSITE-ProRule
Tyrosine-protein phosphatase 2 944-1228 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248348 |
| PTPRC | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248349 |
| PTPRC | JAK2 | – | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248347 | |
| PTPRC | JAK2 | – | dephosphorylation down-regulates activity | 24252238 | SIGNOR-255679 | |
| PTPRC | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 11259588 | SIGNOR-248351 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 11259588 | SIGNOR-248350 |
| PTPRC | LCK | Tyr505 | FTATEGQyQPQP | dephosphorylation up-regulates activity | 17719247 | SIGNOR-259933 |
| PTPRC | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates activity | 11909961 | SIGNOR-248352 |
| PTPRC | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 10415030 | SIGNOR-248353 |
| PTPRC | LYN | Tyr508 | YTATEGQyQQQP | dephosphorylation down-regulates activity | 10415030 | SIGNOR-248354 |
| PTPRC | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248355 |
| PTPRC | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248356 |
| PTPRC | JAK1 | – | dephosphorylation up-regulates | 11994288 | SIGNOR-87154 | |
| PTPRC | TYK2 | Tyr1054 | AVPEGHEyYRVREDG | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248357 |
| PTPRC | TYK2 | Tyr1055 | VPEGHEYyRVREDGD | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248358 |
| PTPRC | JAK3 | – | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248359 | |
| PTPRC | JAK3 | – | dephosphorylation up-regulates | 11994288 | SIGNOR-87157 | |
| PTPRC | PRKCD | – | dephosphorylation down-regulates activity | 11124968 | SIGNOR-277028 | |
| PTPRC | SKAP1 | Tyr232 | EEEKEETyDDIDGFD | dephosphorylation up-regulates activity | 11909961 | SIGNOR-248360 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRC | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11201744 | SIGNOR-248348 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 11201744 | SIGNOR-248349 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 11259588 | SIGNOR-248351 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 11259588 | SIGNOR-248350 |
| PTPRC | dephosphorylation down-regulates ⊣ | LCK PTyr505 | dephosphorylation down-regulates ⊣ | LCK | 17719247 | SIGNOR-259933 |
| PTPRC | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 11909961 | SIGNOR-248352 |
| PTPRC | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 10415030 | SIGNOR-248353 |
| PTPRC | dephosphorylation down-regulates ⊣ | LYN PTyr508 | dephosphorylation up-regulates → | LYN | 10415030 | SIGNOR-248354 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK1 PTyr1034 | dephosphorylation up-regulates → | JAK1 | 11201744 | SIGNOR-248355 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK1 PTyr1035 | dephosphorylation up-regulates → | JAK1 | 11201744 | SIGNOR-248356 |
| PTPRC | dephosphorylation down-regulates ⊣ | TYK2 PTyr1054 | dephosphorylation up-regulates → | TYK2 | 11201744 | SIGNOR-248357 |
| PTPRC | dephosphorylation down-regulates ⊣ | TYK2 PTyr1055 | dephosphorylation up-regulates → | TYK2 | 11201744 | SIGNOR-248358 |
| PTPRC | dephosphorylation down-regulates ⊣ | SKAP1 PTyr232 | dephosphorylation down-regulates ⊣ | SKAP1 | 11909961 | SIGNOR-248360 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248348 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248349 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248347 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-255679 |
| PTPRC | dephosphorylation → down-regulates activity | LCK | SIGNOR-248351 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-248350 |
| PTPRC | dephosphorylation → up-regulates activity | LCK | SIGNOR-259933 |
| PTPRC | dephosphorylation → up-regulates activity | FYN | SIGNOR-248352 |
| PTPRC | dephosphorylation → down-regulates activity | LYN | SIGNOR-248353 |
| PTPRC | dephosphorylation → down-regulates activity | LYN | SIGNOR-248354 |
| PTPRC | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248355 |
| PTPRC | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248356 |
| PTPRC | dephosphorylation → up-regulates | JAK1 | SIGNOR-87154 |
| PTPRC | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-248357 |
| PTPRC | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-248358 |
| PTPRC | dephosphorylation → down-regulates activity | JAK3 | SIGNOR-248359 |
| PTPRC | dephosphorylation → up-regulates | JAK3 | SIGNOR-87157 |
| PTPRC | dephosphorylation → down-regulates activity | PRKCD | SIGNOR-277028 |
| PTPRC | dephosphorylation → up-regulates activity | SKAP1 | SIGNOR-248360 |