| Name | HCK |
| ID | P08631 |
| Role | kinase |
| Enzymatic Domains |
SH3 78-138 PROSITE-ProRule
SH2 144-241 PROSITE-ProRule
Protein kinase 262-515 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | GLI1 | – | phosphorylation up-regulates activity | 26619401 | SIGNOR-279374 | |
| HCK | HCK | Tyr522 | YTATESQyQQQP | phosphorylation down-regulates | 10934191 | SIGNOR-76996 |
| HCK | HCK | Tyr411 | RVIEDNEyTAREGAK | phosphorylation up-regulates | 10934191 | SIGNOR-80340 |
| HCK | HCK | Tyr411 | RVIEDNEyTAREGAK | phosphorylation up-regulates activity | 10934191 | SIGNOR-251266 |
| HCK | HCK | Tyr51 | ASPHCPVyVPDPTST | phosphorylation up-regulates activity | 10934191 | SIGNOR-251265 |
| HCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249363 |
| HCK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 7682059 | SIGNOR-249364 |
| HCK | PLCG1 | Tyr1253 | EGSFESRyQQPFEDF | phosphorylation up-regulates activity | 7682059 | SIGNOR-249360 |
| HCK | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 7682059 | SIGNOR-249361 |
| HCK | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-249362 |
| HCK | CBL | – | phosphorylation unknown | 10092522 | SIGNOR-251262 | |
| HCK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 12244095 | SIGNOR-251267 |
| HCK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 12235133 | SIGNOR-251268 |
| HCK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 12235133 | SIGNOR-273957 |
| HCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation unknown | 11741929 | SIGNOR-112927 |
| HCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation up-regulates | 11741929 | SIGNOR-112919 |
| HCK | ADAM15 | Tyr735 | LKGPTCQyRAAQSGP | phosphorylation up-regulates | 11741929 | SIGNOR-112923 |
| HCK | RAPGEF1 | Tyr504 | APIPSVPyAPFAAIL | phosphorylation up-regulates | 24396067 | SIGNOR-203613 |
| HCK | ELMO1 | Tyr18 | AIEWPGAyPKLMEID | phosphorylation up-regulates | 15952790 | SIGNOR-138142 |
| HCK | ELMO1 | Tyr216 | VLNSHDLyQKVAQEI | phosphorylation up-regulates | 15952790 | SIGNOR-138146 |
| HCK | ELMO1 | Tyr395 | AKHHQDAyIRIVLEN | phosphorylation up-regulates | 15952790 | SIGNOR-138150 |
| HCK | ELMO1 | Tyr511 | SKLQNLSyTEILKIR | phosphorylation up-regulates | 15952790 | SIGNOR-138154 |
| HCK | ELMO1 | Tyr720 | IPKEPSNyDFVYDCN | phosphorylation up-regulates | 15952790 | SIGNOR-138158 |
| HCK | CSF3R | Tyr752 | GTSDQVLyGQLLGSP | phosphorylation up-regulates activity | 9790917 | SIGNOR-251263 |
| HCK | CSF3R | Tyr787 | LTPSPKSyENLWFQA | phosphorylation up-regulates activity | 9790917 | SIGNOR-251264 |
| HCK | TBK1 | Tyr354 | SSNQELIyEGRRLVL | phosphorylation down-regulates activity | 28618271 | SIGNOR-276726 |
| HCK | TBK1 | Tyr394 | LNTIGLIyEKISLPK | phosphorylation down-regulates activity | 28618271 | SIGNOR-276727 |
| HCK | BCR-ABL | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation up-regulates | 9407116 | SIGNOR-53964 |
| HCK | BCR-ABL | Tyr730 | PNLFVALyDFVASGD | phosphorylation up-regulates activity | 16912036 | SIGNOR-260810 |
| HCK | BCR-ABL | Tyr775 | QGWVPSNyITPVNSL | phosphorylation up-regulates activity | 16912036 | SIGNOR-260811 |
| HCK | BCR-ABL | Tyr788 | SLEKHSWyHGPVSRN | phosphorylation up-regulates activity | 16912036 | SIGNOR-260813 |
| HCK | BCR-ABL | Tyr798 | VSRNAAEyLLSSGIN | phosphorylation up-regulates activity | 16912036 | SIGNOR-260812 |
| HCK | BCR-ABL | Tyr832 | LRYEGRVyHYRINTA | phosphorylation up-regulates activity | 16912036 | SIGNOR-260814 |
| HCK | BCR-ABL | Tyr845 | TASDGKLyVSSESRF | phosphorylation up-regulates activity | 16912036 | SIGNOR-260815 |
| HCK | BCR-ABL | Tyr875 | GLITTLHyPAPKRNK | phosphorylation up-regulates activity | 16912036 | SIGNOR-260816 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | phosphorylation up-regulates → | HCK PTyr522 | phosphorylation down-regulates ⊣ | HCK | 10934191 | SIGNOR-76996 |
| HCK | phosphorylation up-regulates → | HCK PTyr411 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-80340 |
| HCK | phosphorylation up-regulates → | HCK PTyr411 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-251266 |
| HCK | phosphorylation up-regulates → | HCK PTyr51 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-251265 |
| HCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249363 |
| HCK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249364 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr1253 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249360 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249361 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249362 |
| HCK | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 12244095 | SIGNOR-251267 |
| HCK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 12235133 | SIGNOR-251268 |
| HCK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 12235133 | SIGNOR-273957 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation down-regulates ⊣ | ADAM15 | 11741929 | SIGNOR-112927 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112919 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr735 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112923 |
| HCK | phosphorylation up-regulates → | RAPGEF1 PTyr504 | phosphorylation up-regulates → | RAPGEF1 | 24396067 | SIGNOR-203613 |
| HCK | phosphorylation up-regulates → | ELMO1 PTyr18 | phosphorylation up-regulates → | ELMO1 | 15952790 | SIGNOR-138142 |
| HCK | phosphorylation up-regulates → | ELMO1 PTyr216 | phosphorylation up-regulates → | ELMO1 | 15952790 | SIGNOR-138146 |
| HCK | phosphorylation up-regulates → | ELMO1 PTyr395 | phosphorylation up-regulates → | ELMO1 | 15952790 | SIGNOR-138150 |
| HCK | phosphorylation up-regulates → | ELMO1 PTyr511 | phosphorylation up-regulates → | ELMO1 | 15952790 | SIGNOR-138154 |
| HCK | phosphorylation up-regulates → | ELMO1 PTyr720 | phosphorylation up-regulates → | ELMO1 | 15952790 | SIGNOR-138158 |
| HCK | phosphorylation up-regulates → | CSF3R PTyr752 | phosphorylation up-regulates → | CSF3R | 9790917 | SIGNOR-251263 |
| HCK | phosphorylation up-regulates → | CSF3R PTyr787 | phosphorylation up-regulates → | CSF3R | 9790917 | SIGNOR-251264 |
| HCK | phosphorylation up-regulates → | TBK1 PTyr354 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276726 |
| HCK | phosphorylation up-regulates → | TBK1 PTyr394 | phosphorylation down-regulates ⊣ | TBK1 | 28618271 | SIGNOR-276727 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr177 | phosphorylation up-regulates → | BCR-ABL | 9407116 | SIGNOR-53964 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr730 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260810 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr775 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260811 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr788 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260813 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr798 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260812 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr832 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260814 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr845 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260815 |
| HCK | phosphorylation up-regulates → | BCR-ABL PTyr875 | phosphorylation up-regulates → | BCR-ABL | 16912036 | SIGNOR-260816 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HCK | phosphorylation → up-regulates activity | GLI1 | SIGNOR-279374 |
| HCK | phosphorylation down-regulates | HCK | SIGNOR-76996 |
| HCK | phosphorylation → up-regulates | HCK | SIGNOR-80340 |
| HCK | phosphorylation → up-regulates activity | HCK | SIGNOR-251266 |
| HCK | phosphorylation → up-regulates activity | HCK | SIGNOR-251265 |
| HCK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249363 |
| HCK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249364 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249360 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249361 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249362 |
| HCK | phosphorylation → unknown | CBL | SIGNOR-251262 |
| HCK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-251267 |
| HCK | phosphorylation → up-regulates activity | WAS | SIGNOR-251268 |
| HCK | phosphorylation → up-regulates activity | WAS | SIGNOR-273957 |
| HCK | phosphorylation → unknown | ADAM15 | SIGNOR-112927 |
| HCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112919 |
| HCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112923 |
| HCK | phosphorylation → up-regulates | RAPGEF1 | SIGNOR-203613 |
| HCK | phosphorylation → up-regulates | ELMO1 | SIGNOR-138142 |
| HCK | phosphorylation → up-regulates | ELMO1 | SIGNOR-138146 |
| HCK | phosphorylation → up-regulates | ELMO1 | SIGNOR-138150 |
| HCK | phosphorylation → up-regulates | ELMO1 | SIGNOR-138154 |
| HCK | phosphorylation → up-regulates | ELMO1 | SIGNOR-138158 |
| HCK | phosphorylation → up-regulates activity | CSF3R | SIGNOR-251263 |
| HCK | phosphorylation → up-regulates activity | CSF3R | SIGNOR-251264 |
| HCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276726 |
| HCK | phosphorylation → down-regulates activity | TBK1 | SIGNOR-276727 |
| HCK | phosphorylation → up-regulates | BCR-ABL | SIGNOR-53964 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260810 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260811 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260813 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260812 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260814 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260815 |
| HCK | phosphorylation → up-regulates activity | BCR-ABL | SIGNOR-260816 |