| Name | HCK |
| ID | P08631 |
| Role | substrate |
| Enzymatic Domains |
SH3 78-138 PROSITE-ProRule
SH2 144-241 PROSITE-ProRule
Protein kinase 262-515 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | HCK | Tyr522 | YTATESQyQQQP | phosphorylation down-regulates | 10934191 | SIGNOR-76996 |
| HCK | HCK | Tyr51 | ASPHCPVyVPDPTST | phosphorylation up-regulates activity | 10934191 | SIGNOR-251265 |
| HCK | HCK | Tyr411 | RVIEDNEyTAREGAK | phosphorylation up-regulates | 10934191 | SIGNOR-80340 |
| HCK | HCK | Tyr411 | RVIEDNEyTAREGAK | phosphorylation up-regulates activity | 10934191 | SIGNOR-251266 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HCK | phosphorylation up-regulates → | HCK PTyr522 | phosphorylation down-regulates ⊣ | HCK | 10934191 | SIGNOR-76996 |
| HCK | phosphorylation up-regulates → | HCK PTyr51 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-251265 |
| HCK | phosphorylation up-regulates → | HCK PTyr411 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-80340 |
| HCK | phosphorylation up-regulates → | HCK PTyr411 | phosphorylation up-regulates → | HCK | 10934191 | SIGNOR-251266 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HCK | phosphorylation down-regulates | HCK | SIGNOR-76996 |
| HCK | phosphorylation → up-regulates activity | HCK | SIGNOR-251265 |
| HCK | phosphorylation → up-regulates | HCK | SIGNOR-80340 |
| HCK | phosphorylation → up-regulates activity | HCK | SIGNOR-251266 |