Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PAK2	VIM	Ser26 View in OncoXplorer	GTASRPSsSRSYVTT	phosphorylation down-regulates activity	11895474	SIGNOR-250237
PRKCA	VIM	Ser27 View in OncoXplorer	TASRPSSsRSYVTTS	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248879
PRKACA	VIM	Ser7 View in OncoXplorer	sSSSYRRM	phosphorylation down-regulates activity	2500966	SIGNOR-250071
CDK5	VIM	Ser56 View in OncoXplorer	SRSLYASsPGGVYAT	phosphorylation up-regulates activity	21465480	SIGNOR-278922
PAK2	VIM	Ser66 View in OncoXplorer	GVYATRSsAVRLRSS	phosphorylation down-regulates activity	11895474	SIGNOR-250241
PAK2	VIM	Ser39 View in OncoXplorer	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	11895474	SIGNOR-250239
ROCK1	VIM	Ser72 View in OncoXplorer	SSAVRLRsSVPGVRL	phosphorylation down-regulates activity	9565595	SIGNOR-248998
PRKCA	VIM	Ser26 View in OncoXplorer	GTASRPSsSRSYVTT	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248882
PRKCA	VIM	Ser42 View in OncoXplorer	TRTYSLGsALRPSTS	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248881
PRKCA	VIM	Ser22 View in OncoXplorer	FGGPGTAsRPSSSRS	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248878
AURKB	VIM	Ser73 View in OncoXplorer	SAVRLRSsVPGVRLL	phosphorylation down-regulates	12458200	SIGNOR-96057
CDK1	VIM	Ser55 View in OncoXplorer	TSRSLYAsSPGGVYA	phosphorylation down-regulates	7983050	SIGNOR-35492
PRKCA	VIM	Ser9 View in OncoXplorer	STRSVSSsSYRRMFG	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248876
PAK	VIM	–		phosphorylation down-regulates activity	11895474	SIGNOR-269975
PRKCA	VIM	Ser66 View in OncoXplorer	GVYATRSsAVRLRSS	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248884
PRKCA	VIM	Ser51 View in OncoXplorer	LRPSTSRsLYASSPG	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248883
AKT1	VIM	Ser39 View in OncoXplorer	TTSTRTYsLGSALRP	phosphorylation up-regulates quantity by stabilization	20856200	SIGNOR-252511
PRKACA	VIM	Ser66 View in OncoXplorer	GVYATRSsAVRLRSS	phosphorylation down-regulates activity	2500966	SIGNOR-250068
PRKCA	VIM	Ser7 View in OncoXplorer	sSSSYRRM	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248886
PRKACA	VIM	Ser47 View in OncoXplorer	LGSALRPsTSRSLYA	phosphorylation down-regulates activity	2500966	SIGNOR-250070
PLK1	VIM	Ser83 View in OncoXplorer	GVRLLQDsVDFSLAD	phosphorylation up-regulates	18056432	SIGNOR-159386
PAK2	VIM	Ser73 View in OncoXplorer	SAVRLRSsVPGVRLL	phosphorylation down-regulates activity	11895474	SIGNOR-250243
PRKCA	VIM	Ser34 View in OncoXplorer	SRSYVTTsTRTYSLG	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248880
PRKCB	VIM	–		phosphorylation up-regulates quantity	23974215	SIGNOR-278984
PRKACA	VIM	Ser25 View in OncoXplorer	PGTASRPsSSRSYVT	phosphorylation down-regulates activity	2500966	SIGNOR-250066
PRKCA	VIM	Ser10 View in OncoXplorer	TRSVSSSsYRRMFGG	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248877
PRKACA	VIM	Ser51 View in OncoXplorer	LRPSTSRsLYASSPG	phosphorylation down-regulates activity	2500966	SIGNOR-250069
PRKCZ	VIM	Ser34 View in OncoXplorer	SRSYVTTsTRTYSLG	phosphorylation up-regulates activity	33525953	SIGNOR-277622
AKT	VIM	Ser39 View in OncoXplorer	TTSTRTYsLGSALRP	phosphorylation up-regulates quantity by stabilization	20856200	SIGNOR-167971
CAMK2D	VIM	Ser83 View in OncoXplorer	GVRLLQDsVDFSLAD	phosphorylation unknown	16140754	SIGNOR-250690
PRKACA	VIM	Ser39 View in OncoXplorer	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	2500966	SIGNOR-250067
PRKCI	VIM	Ser34 View in OncoXplorer	SRSYVTTsTRTYSLG	phosphorylation up-regulates activity	33525953	SIGNOR-277623
PRKCA	VIM	Ser39 View in OncoXplorer	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	2500966	SIGNOR-248885
PAK1	VIM	Ser56 View in OncoXplorer	SRSLYASsPGGVYAT	phosphorylation unknown	15766329	SIGNOR-134520

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PAK2	phosphorylation up-regulates →	VIM PSer26	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250237
PRKCA	phosphorylation up-regulates →	VIM PSer27	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248879
PRKACA	phosphorylation up-regulates →	VIM PSer7	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250071
CDK5	phosphorylation up-regulates →	VIM PSer56	phosphorylation up-regulates →	VIM	21465480	SIGNOR-278922
PAK2	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250241
PAK2	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250239
ROCK1	phosphorylation up-regulates →	VIM PSer72	phosphorylation down-regulates ⊣	VIM	9565595	SIGNOR-248998
PRKCA	phosphorylation up-regulates →	VIM PSer26	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248882
PRKCA	phosphorylation up-regulates →	VIM PSer42	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248881
PRKCA	phosphorylation up-regulates →	VIM PSer22	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248878
AURKB	phosphorylation up-regulates →	VIM PSer73	phosphorylation down-regulates ⊣	VIM	12458200	SIGNOR-96057
CDK1	phosphorylation up-regulates →	VIM PSer55	phosphorylation down-regulates ⊣	VIM	7983050	SIGNOR-35492
PRKCA	phosphorylation up-regulates →	VIM PSer9	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248876
PRKCA	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248884
PRKCA	phosphorylation up-regulates →	VIM PSer51	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248883
AKT1	phosphorylation up-regulates →	VIM PSer39	phosphorylation up-regulates →	VIM	20856200	SIGNOR-252511
PRKACA	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250068
PRKCA	phosphorylation up-regulates →	VIM PSer7	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248886
PRKACA	phosphorylation up-regulates →	VIM PSer47	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250070
PLK1	phosphorylation up-regulates →	VIM PSer83	phosphorylation up-regulates →	VIM	18056432	SIGNOR-159386
PAK2	phosphorylation up-regulates →	VIM PSer73	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250243
PRKCA	phosphorylation up-regulates →	VIM PSer34	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248880
PRKACA	phosphorylation up-regulates →	VIM PSer25	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250066
PRKCA	phosphorylation up-regulates →	VIM PSer10	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248877
PRKACA	phosphorylation up-regulates →	VIM PSer51	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250069
PRKCZ	phosphorylation up-regulates →	VIM PSer34	phosphorylation up-regulates →	VIM	33525953	SIGNOR-277622
AKT	phosphorylation up-regulates →	VIM PSer39	phosphorylation up-regulates →	VIM	20856200	SIGNOR-167971
CAMK2D	phosphorylation up-regulates →	VIM PSer83	phosphorylation down-regulates ⊣	VIM	16140754	SIGNOR-250690
PRKACA	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250067
PRKCI	phosphorylation up-regulates →	VIM PSer34	phosphorylation up-regulates →	VIM	33525953	SIGNOR-277623
PRKCA	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248885
PAK1	phosphorylation up-regulates →	VIM PSer56	phosphorylation down-regulates ⊣	VIM	15766329	SIGNOR-134520

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250237
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248879
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250071
CDK5	phosphorylation → up-regulates activity	VIM	SIGNOR-278922
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250241
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250239
ROCK1	phosphorylation → down-regulates activity	VIM	SIGNOR-248998
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248882
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248881
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248878
AURKB	phosphorylation down-regulates	VIM	SIGNOR-96057
CDK1	phosphorylation down-regulates	VIM	SIGNOR-35492
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248876
PAK	phosphorylation → down-regulates activity	VIM	SIGNOR-269975
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248884
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248883
AKT1	phosphorylation → up-regulates quantity by stabilization	VIM	SIGNOR-252511
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250068
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248886
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250070
PLK1	phosphorylation → up-regulates	VIM	SIGNOR-159386
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250243
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248880
PRKCB	phosphorylation → up-regulates quantity	VIM	SIGNOR-278984
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250066
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248877
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250069
PRKCZ	phosphorylation → up-regulates activity	VIM	SIGNOR-277622
AKT	phosphorylation → up-regulates quantity by stabilization	VIM	SIGNOR-167971
CAMK2D	phosphorylation → unknown	VIM	SIGNOR-250690
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250067
PRKCI	phosphorylation → up-regulates activity	VIM	SIGNOR-277623
PRKCA	phosphorylation → down-regulates activity	VIM	SIGNOR-248885
PAK1	phosphorylation → unknown	VIM	SIGNOR-134520