Entity Details

Name	AKT_Ser39
ID	P08670
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PAK2	VIM	Ser39	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	11895474	SIGNOR-250239
PRKACA	VIM	Ser39	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	2500966	SIGNOR-250067
AKT	VIM	Ser39	TTSTRTYsLGSALRP	phosphorylation up-regulates quantity by stabilization	20856200	SIGNOR-167971
PRKCA	VIM	Ser39	TTSTRTYsLGSALRP	phosphorylation down-regulates activity	2500966	SIGNOR-248885
AKT1	VIM	Ser39	TTSTRTYsLGSALRP	phosphorylation up-regulates quantity by stabilization	20856200	SIGNOR-252511

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PAK2	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250239
PRKACA	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250067
AKT	phosphorylation up-regulates →	VIM PSer39	phosphorylation up-regulates →	VIM	20856200	SIGNOR-167971
PRKCA	phosphorylation up-regulates →	VIM PSer39	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248885
AKT1	phosphorylation up-regulates →	VIM PSer39	phosphorylation up-regulates →	VIM	20856200	SIGNOR-252511

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250239
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250067
AKT	phosphorylation → up-regulates quantity by stabilization	VIM	SIGNOR-167971
PRKCA	phosphorylation → down-regulates activity	VIM	SIGNOR-248885
AKT1	phosphorylation → up-regulates quantity by stabilization	VIM	SIGNOR-252511