Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKACA	VIM	Ser66	GVYATRSsAVRLRSS	phosphorylation down-regulates activity	2500966	SIGNOR-250068
PRKCA	VIM	Ser66	GVYATRSsAVRLRSS	phosphorylation down-regulates quantity by destabilization	2500966	SIGNOR-248884
PAK2	VIM	Ser66	GVYATRSsAVRLRSS	phosphorylation down-regulates activity	11895474	SIGNOR-250241

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKACA	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-250068
PRKCA	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	2500966	SIGNOR-248884
PAK2	phosphorylation up-regulates →	VIM PSer66	phosphorylation down-regulates ⊣	VIM	11895474	SIGNOR-250241

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKACA	phosphorylation → down-regulates activity	VIM	SIGNOR-250068
PRKCA	phosphorylation down-regulates quantity by destabilization	VIM	SIGNOR-248884
PAK2	phosphorylation → down-regulates activity	VIM	SIGNOR-250241