| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | VIM | Ser34 | SRSYVTTsTRTYSLG | phosphorylation up-regulates activity | 33525953 | SIGNOR-277622 |
| PRKCI | VIM | Ser34 | SRSYVTTsTRTYSLG | phosphorylation up-regulates activity | 33525953 | SIGNOR-277623 |
| PRKCA | VIM | Ser34 | SRSYVTTsTRTYSLG | phosphorylation down-regulates quantity by destabilization | 2500966 | SIGNOR-248880 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCZ | phosphorylation up-regulates → | VIM PSer34 | phosphorylation up-regulates → | VIM | 33525953 | SIGNOR-277622 |
| PRKCI | phosphorylation up-regulates → | VIM PSer34 | phosphorylation up-regulates → | VIM | 33525953 | SIGNOR-277623 |
| PRKCA | phosphorylation up-regulates → | VIM PSer34 | phosphorylation down-regulates ⊣ | VIM | 2500966 | SIGNOR-248880 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCZ | phosphorylation → up-regulates activity | VIM | SIGNOR-277622 |
| PRKCI | phosphorylation → up-regulates activity | VIM | SIGNOR-277623 |
| PRKCA | phosphorylation down-regulates quantity by destabilization | VIM | SIGNOR-248880 |
