| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | VIM | Ser51 | LRPSTSRsLYASSPG | phosphorylation down-regulates activity | 2500966 | SIGNOR-250069 |
| PRKCA | VIM | Ser51 | LRPSTSRsLYASSPG | phosphorylation down-regulates quantity by destabilization | 2500966 | SIGNOR-248883 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | VIM PSer51 | phosphorylation down-regulates ⊣ | VIM | 2500966 | SIGNOR-250069 |
| PRKCA | phosphorylation up-regulates → | VIM PSer51 | phosphorylation down-regulates ⊣ | VIM | 2500966 | SIGNOR-248883 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | VIM | SIGNOR-250069 |
| PRKCA | phosphorylation down-regulates quantity by destabilization | VIM | SIGNOR-248883 |
