| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | VIM | Ser73 | SAVRLRSsVPGVRLL | phosphorylation down-regulates activity | 11895474 | SIGNOR-250243 |
| AURKB | VIM | Ser73 | SAVRLRSsVPGVRLL | phosphorylation down-regulates | 12458200 | SIGNOR-96057 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | phosphorylation up-regulates → | VIM PSer73 | phosphorylation down-regulates ⊣ | VIM | 11895474 | SIGNOR-250243 |
| AURKB | phosphorylation up-regulates → | VIM PSer73 | phosphorylation down-regulates ⊣ | VIM | 12458200 | SIGNOR-96057 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK2 | phosphorylation → down-regulates activity | VIM | SIGNOR-250243 |
| AURKB | phosphorylation down-regulates | VIM | SIGNOR-96057 |
