Entity Details

Name ADRA2A
ID P08913
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GRK2ADRA2ASer311DALDLEEsSSSDHAEphosphorylation
down-regulates activity		7876239SIGNOR-251440
GRK2ADRA2ASer312ALDLEESsSSDHAERphosphorylation
down-regulates activity		7876239SIGNOR-251441
PRKCDADRA2ASer247RRTRVPPsRRGPDAVphosphorylation
up-regulates activity		11732925SIGNOR-249126
GRK2ADRA2ASer314DLEESSSsDHAERPPphosphorylation
down-regulates activity		7876239SIGNOR-251443
GRK2ADRA2ASer313LDLEESSsSDHAERPphosphorylation
down-regulates activity		7876239SIGNOR-251442
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GRK2phosphorylation
up-regulates
→
ADRA2A
PSer311		phosphorylation
down-regulates
⊣		ADRA2A7876239SIGNOR-251440
GRK2phosphorylation
up-regulates
→
ADRA2A
PSer312		phosphorylation
down-regulates
⊣		ADRA2A7876239SIGNOR-251441
PRKCDphosphorylation
up-regulates
→
ADRA2A
PSer247		phosphorylation
up-regulates
→		ADRA2A11732925SIGNOR-249126
GRK2phosphorylation
up-regulates
→
ADRA2A
PSer314		phosphorylation
down-regulates
⊣		ADRA2A7876239SIGNOR-251443
GRK2phosphorylation
up-regulates
→
ADRA2A
PSer313		phosphorylation
down-regulates
⊣		ADRA2A7876239SIGNOR-251442
Regulator Mechanism/Effect Target SIGNOR-ID
GRK2phosphorylation
→
down-regulates activity 		ADRA2ASIGNOR-251440
GRK2phosphorylation
→
down-regulates activity 		ADRA2ASIGNOR-251441
PRKCDphosphorylation
→
up-regulates activity 		ADRA2ASIGNOR-249126
GRK2phosphorylation
→
down-regulates activity 		ADRA2ASIGNOR-251443
GRK2phosphorylation
→
down-regulates activity 		ADRA2ASIGNOR-251442