| Name | ROS1 |
| ID | P08922 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 1 101-196 PROSITE-ProRule
Fibronectin type-III 2 197-285 PROSITE-ProRule
Fibronectin type-III 3 557-671 PROSITE-ProRule
Fibronectin type-III 4 947-1042 PROSITE-ProRule
Fibronectin type-III 5 1043-1150 PROSITE-ProRule
Fibronectin type-III 6 1450-1556 PROSITE-ProRule
Fibronectin type-III 7 1557-1656 PROSITE-ProRule
Fibronectin type-III 8 1658-1751 PROSITE-ProRule
Fibronectin type-III 9 1752-1854 PROSITE-ProRule
Protein kinase 1945-2222 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | ROS1 | Tyr2274 | KNREGLNyMVLATEC | dephosphorylation down-regulates | 11266449 | SIGNOR-105919 |
| PTPN1 | ROS1 | Tyr2115 | DIYKNDYyRKRGEGL | dephosphorylation down-regulates | 17416557 | SIGNOR-154207 |
| PTPN6 | ROS1 | – | dephosphorylation down-regulates | 11266449 | SIGNOR-105922 | |
| PTPN1 | ROS1 | Tyr2114 | RDIYKNDyYRKRGEG | dephosphorylation down-regulates | 17416557 | SIGNOR-154203 |
| PTPN1 | ROS1 | Tyr2110 | FGLARDIyKNDYYRK | dephosphorylation down-regulates | 17416557 | SIGNOR-154199 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2274 | dephosphorylation up-regulates → | ROS1 | 11266449 | SIGNOR-105919 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2115 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154207 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2114 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154203 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2110 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154199 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates | ROS1 | SIGNOR-105919 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154207 |
| PTPN6 | dephosphorylation down-regulates | ROS1 | SIGNOR-105922 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154203 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154199 |