Entity Details

Name FGR
ID P09769
Role kinase
Enzymatic Domains
SH3 77-138
PROSITE-ProRule
SH2 144-241
PROSITE-ProRule
Protein kinase 263-516
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FGRFGRTyr412 RLIKDDEyNPCQGSKphosphorylation
up-regulates activity
8612628SIGNOR-251143
FGRSRCTyr530FTSTEPQyQPGENLphosphorylation
unknown
9208935SIGNOR-251145
FGRHCLS1Tyr222MEAPTTAyKKTTPIEphosphorylation
unknown
10066823SIGNOR-251144
FGRSDHATyr543CGKISKLyGDLKHLKphosphorylation
unknown
17997986SIGNOR-262872
FGRSDHATyr604YKVRIDEyDYSKPIQphosphorylation
unknown
17997986SIGNOR-262873
FGRSYK–phosphorylation
up-regulates activity
21746961SIGNOR-279332
FGRGLO1Tyr136GIAVPDVySACKRFEphosphorylation
up-regulates activity
34838714SIGNOR-276188
FGRPTK2Tyr925DRSNDKVyENVTGLVphosphorylation
up-regulates
12387730SIGNOR-94405
FGRACO2Tyr544FDPGQDTyQHPPKDSphosphorylation
unknown
17997986SIGNOR-262869
FGRACO2Tyr665VVIGDENyGEGSSREphosphorylation
unknown
17997986SIGNOR-262870
FGRACO2Tyr71TLSEKIVyGHLDDPAphosphorylation
unknown
17997986SIGNOR-262871
FGRTBK1Tyr354SSNQELIyEGRRLVLphosphorylation
down-regulates activity
28618271SIGNOR-276725
FGRTBK1Tyr394LNTIGLIyEKISLPKphosphorylation
down-regulates activity
28618271SIGNOR-276722
FGRKCND3Tyr108GKLHYPRyECISAYDphosphorylation
up-regulates activity
22198508SIGNOR-276394
FGRIKBKGTyr374PLPPAPAyLSSPLALphosphorylation
down-regulates activity
23131831SIGNOR-276368
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FGRphosphorylation
up-regulates
→
FGR
PTyr412
phosphorylation
up-regulates
→
FGR8612628SIGNOR-251143
FGRphosphorylation
up-regulates
→
SRC
PTyr530
phosphorylation
down-regulates
⊣
SRC9208935SIGNOR-251145
FGRphosphorylation
up-regulates
→
HCLS1
PTyr222
phosphorylation
down-regulates
⊣
HCLS110066823SIGNOR-251144
FGRphosphorylation
up-regulates
→
SDHA
PTyr543
phosphorylation
down-regulates
⊣
SDHA17997986SIGNOR-262872
FGRphosphorylation
up-regulates
→
SDHA
PTyr604
phosphorylation
down-regulates
⊣
SDHA17997986SIGNOR-262873
FGRphosphorylation
up-regulates
→
GLO1
PTyr136
phosphorylation
up-regulates
→
GLO134838714SIGNOR-276188
FGRphosphorylation
up-regulates
→
PTK2
PTyr925
phosphorylation
up-regulates
→
PTK212387730SIGNOR-94405
FGRphosphorylation
up-regulates
→
ACO2
PTyr544
phosphorylation
down-regulates
⊣
ACO217997986SIGNOR-262869
FGRphosphorylation
up-regulates
→
ACO2
PTyr665
phosphorylation
down-regulates
⊣
ACO217997986SIGNOR-262870
FGRphosphorylation
up-regulates
→
ACO2
PTyr71
phosphorylation
down-regulates
⊣
ACO217997986SIGNOR-262871
FGRphosphorylation
up-regulates
→
TBK1
PTyr354
phosphorylation
down-regulates
⊣
TBK128618271SIGNOR-276725
FGRphosphorylation
up-regulates
→
TBK1
PTyr394
phosphorylation
down-regulates
⊣
TBK128618271SIGNOR-276722
FGRphosphorylation
up-regulates
→
KCND3
PTyr108
phosphorylation
up-regulates
→
KCND322198508SIGNOR-276394
FGRphosphorylation
up-regulates
→
IKBKG
PTyr374
phosphorylation
down-regulates
⊣
IKBKG23131831SIGNOR-276368
Regulator Mechanism/Effect Target SIGNOR-ID
FGRphosphorylation
→
up-regulates activity
FGRSIGNOR-251143
FGRphosphorylation
→
unknown
SRCSIGNOR-251145
FGRphosphorylation
→
unknown
HCLS1SIGNOR-251144
FGRphosphorylation
→
unknown
SDHASIGNOR-262872
FGRphosphorylation
→
unknown
SDHASIGNOR-262873
FGRphosphorylation
→
up-regulates activity
SYKSIGNOR-279332
FGRphosphorylation
→
up-regulates activity
GLO1SIGNOR-276188
FGRphosphorylation
→
up-regulates
PTK2SIGNOR-94405
FGRphosphorylation
→
unknown
ACO2SIGNOR-262869
FGRphosphorylation
→
unknown
ACO2SIGNOR-262870
FGRphosphorylation
→
unknown
ACO2SIGNOR-262871
FGRphosphorylation
→
down-regulates activity
TBK1SIGNOR-276725
FGRphosphorylation
→
down-regulates activity
TBK1SIGNOR-276722
FGRphosphorylation
→
up-regulates activity
KCND3SIGNOR-276394
FGRphosphorylation
→
down-regulates activity
IKBKGSIGNOR-276368