| Name | PARP1 |
| ID | P09874 |
| Role | substrate |
| Enzymatic Domains |
PADR1 zinc-binding 225-359 PROSITE-ProRule
BRCT 385-476 PROSITE-ProRule
WGR 542-638 PROSITE-ProRule
PARP alpha-helical 662-779 PROSITE-ProRule
PARP catalytic 788-1014 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | PARP1 | – | phosphorylation up-regulates activity | 22948662 | SIGNOR-279146 | |
| ATR | PARP1 | Ser179 | FRPEYSAsQLKGFSL | phosphorylation down-regulates | 33811702 | SIGNOR-278506 |
| ERK1/2 | PARP1 | Ser372 | VAATPPPsTASAPAA | phosphorylation up-regulates | 16627622 | SIGNOR-244669 |
| EGFR | PARP1 | – | phosphorylation up-regulates activity | 30573522 | SIGNOR-279169 | |
| PRKACA | PARP1 | Ser782 | YSLLRGGsDDSSKDP | phosphorylation up-regulates activity | 25069723 | SIGNOR-276652 |
| CDK5 | PARP1 | Ser785 | LRGGSDDsSKDPIDV | phosphorylation down-regulates activity | 21922195 | SIGNOR-276358 |
| PRKACA | PARP1 | Ser785 | LRGGSDDsSKDPIDV | phosphorylation up-regulates activity | 25069723 | SIGNOR-276653 |
| CDK5 | PARP1 | Ser782 | YSLLRGGsDDSSKDP | phosphorylation down-regulates activity | 21922195 | SIGNOR-276357 |
| PRKACA | PARP1 | Ser465 | FLQDVSAsTKSLQEL | phosphorylation up-regulates activity | 25069723 | SIGNOR-276651 |
| ATR | PARP1 | Ser179 | FRPEYSAsQLKGFSL | phosphorylation down-regulates activity | 33811702 | SIGNOR-277551 |
| ERK1/2 | PARP1 | Thr373 | AATPPPStASAPAAV | phosphorylation up-regulates | 16627622 | SIGNOR-244673 |
| MAPK1 | PARP1 | Ser372 | VAATPPPsTASAPAA | phosphorylation up-regulates | 16627622 | SIGNOR-146220 |
| MAPK1 | PARP1 | Thr373 | AATPPPStASAPAAV | phosphorylation up-regulates | 16627622 | SIGNOR-146224 |
| MET | PARP1 | Tyr907 | MVSKSANyCHTSQGD | phosphorylation up-regulates activity | 26779812 | SIGNOR-279470 |
| PRKCD | PARP1 | – | phosphorylation down-regulates activity | 27198223 | SIGNOR-280085 | |
| PRKDC | PARP1 | – | phosphorylation down-regulates activity | 22504299 | SIGNOR-280093 | |
| CDK5 | PARP1 | Ser786 | RGGSDDSsKDPIDVN | phosphorylation down-regulates activity | 21922195 | SIGNOR-276359 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | PARP1 PSer179 | phosphorylation down-regulates ⊣ | PARP1 | 33811702 | SIGNOR-278506 |
| ERK1/2 | phosphorylation up-regulates → | PARP1 PSer372 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-244669 |
| PRKACA | phosphorylation up-regulates → | PARP1 PSer782 | phosphorylation up-regulates → | PARP1 | 25069723 | SIGNOR-276652 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer785 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276358 |
| PRKACA | phosphorylation up-regulates → | PARP1 PSer785 | phosphorylation up-regulates → | PARP1 | 25069723 | SIGNOR-276653 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer782 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276357 |
| PRKACA | phosphorylation up-regulates → | PARP1 PSer465 | phosphorylation up-regulates → | PARP1 | 25069723 | SIGNOR-276651 |
| ATR | phosphorylation up-regulates → | PARP1 PSer179 | phosphorylation down-regulates ⊣ | PARP1 | 33811702 | SIGNOR-277551 |
| ERK1/2 | phosphorylation up-regulates → | PARP1 PThr373 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-244673 |
| MAPK1 | phosphorylation up-regulates → | PARP1 PSer372 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-146220 |
| MAPK1 | phosphorylation up-regulates → | PARP1 PThr373 | phosphorylation up-regulates → | PARP1 | 16627622 | SIGNOR-146224 |
| MET | phosphorylation up-regulates → | PARP1 PTyr907 | phosphorylation up-regulates → | PARP1 | 26779812 | SIGNOR-279470 |
| CDK5 | phosphorylation up-regulates → | PARP1 PSer786 | phosphorylation down-regulates ⊣ | PARP1 | 21922195 | SIGNOR-276359 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates activity | PARP1 | SIGNOR-279146 |
| ATR | phosphorylation down-regulates | PARP1 | SIGNOR-278506 |
| ERK1/2 | phosphorylation → up-regulates | PARP1 | SIGNOR-244669 |
| EGFR | phosphorylation → up-regulates activity | PARP1 | SIGNOR-279169 |
| PRKACA | phosphorylation → up-regulates activity | PARP1 | SIGNOR-276652 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276358 |
| PRKACA | phosphorylation → up-regulates activity | PARP1 | SIGNOR-276653 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276357 |
| PRKACA | phosphorylation → up-regulates activity | PARP1 | SIGNOR-276651 |
| ATR | phosphorylation → down-regulates activity | PARP1 | SIGNOR-277551 |
| ERK1/2 | phosphorylation → up-regulates | PARP1 | SIGNOR-244673 |
| MAPK1 | phosphorylation → up-regulates | PARP1 | SIGNOR-146220 |
| MAPK1 | phosphorylation → up-regulates | PARP1 | SIGNOR-146224 |
| MET | phosphorylation → up-regulates activity | PARP1 | SIGNOR-279470 |
| PRKCD | phosphorylation → down-regulates activity | PARP1 | SIGNOR-280085 |
| PRKDC | phosphorylation → down-regulates activity | PARP1 | SIGNOR-280093 |
| CDK5 | phosphorylation → down-regulates activity | PARP1 | SIGNOR-276359 |