| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | PARP1 | Ser179 | FRPEYSAsQLKGFSL | phosphorylation down-regulates activity | 33811702 | SIGNOR-277551 |
| ATR | PARP1 | Ser179 | FRPEYSAsQLKGFSL | phosphorylation down-regulates | 33811702 | SIGNOR-278506 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | PARP1 PSer179 | phosphorylation down-regulates ⊣ | PARP1 | 33811702 | SIGNOR-277551 |
| ATR | phosphorylation up-regulates → | PARP1 PSer179 | phosphorylation down-regulates ⊣ | PARP1 | 33811702 | SIGNOR-278506 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → down-regulates activity | PARP1 | SIGNOR-277551 |
| ATR | phosphorylation![]() down-regulates | PARP1 | SIGNOR-278506 |