Entity Details

Name	PARP1_Thr373
ID	P09874
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK1	PARP1	Thr373 View in OncoXplorer	AATPPPStASAPAAV	phosphorylation up-regulates	16627622	SIGNOR-146224
ERK1/2	PARP1	Thr373 View in OncoXplorer	AATPPPStASAPAAV	phosphorylation up-regulates	16627622	SIGNOR-244673

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK1	phosphorylation up-regulates →	PARP1 PThr373	phosphorylation up-regulates →	PARP1	16627622	SIGNOR-146224
ERK1/2	phosphorylation up-regulates →	PARP1 PThr373	phosphorylation up-regulates →	PARP1	16627622	SIGNOR-244673

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK1	phosphorylation → up-regulates	PARP1	SIGNOR-146224
ERK1/2	phosphorylation → up-regulates	PARP1	SIGNOR-244673