| Name | ALOX5 |
| ID | P09917 |
| Role | substrate |
| Enzymatic Domains |
PLAT 2-118 PROSITE-ProRule
Lipoxygenase 119-674 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 18978352 | SIGNOR-264408 |
| MAPKAPK2 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 11844797 | SIGNOR-250143 |
| MAPK1 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 12670876 | SIGNOR-264439 |
| ERK1/2 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264442 |
| MAPK1 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264409 |
| MAPK3 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264440 |
| PRKACA | ALOX5 | Ser524 | GMRGRKSsGFPKSVK | phosphorylation down-regulates activity | 15280375 | SIGNOR-264410 |
| Gbeta | ALOX5 | – | phosphorylation up-regulates activity | 12670876 | SIGNOR-270088 | |
| MAPK3 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 12670876 | SIGNOR-264441 |
| ERK1/2 | ALOX5 | Ser272 | CSLERQLsLEQEVQQ | phosphorylation up-regulates activity | 12670876 | SIGNOR-264443 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 18978352 | SIGNOR-264408 |
| MAPKAPK2 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 11844797 | SIGNOR-250143 |
| MAPK1 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264439 |
| ERK1/2 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264442 |
| MAPK1 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264409 |
| MAPK3 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264440 |
| PRKACA | phosphorylation up-regulates → | ALOX5 PSer524 | phosphorylation down-regulates ⊣ | ALOX5 | 15280375 | SIGNOR-264410 |
| MAPK3 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264441 |
| ERK1/2 | phosphorylation up-regulates → | ALOX5 PSer272 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264443 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264408 |
| MAPKAPK2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-250143 |
| MAPK1 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264439 |
| ERK1/2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264442 |
| MAPK1 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264409 |
| MAPK3 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264440 |
| PRKACA | phosphorylation → down-regulates activity | ALOX5 | SIGNOR-264410 |
| Gbeta | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-270088 |
| MAPK3 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264441 |
| ERK1/2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264443 |