| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264442 |
| MAPK1 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264409 |
| MAPK3 | ALOX5 | Ser664 | QLPYYYLsPDRIPNS | phosphorylation up-regulates activity | 12670876 | SIGNOR-264440 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264442 |
| MAPK1 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264409 |
| MAPK3 | phosphorylation up-regulates → | ALOX5 PSer664 | phosphorylation up-regulates → | ALOX5 | 12670876 | SIGNOR-264440 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264442 |
| MAPK1 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264409 |
| MAPK3 | phosphorylation → up-regulates activity | ALOX5 | SIGNOR-264440 |