| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | GLI2 | – | phosphorylation down-regulates quantity by destabilization | 19056373 | SIGNOR-182573 | |
| ULK3 | GLI2 | – | phosphorylation up-regulates activity | 19878745 | SIGNOR-260798 | |
| CSNK1A1 | GLI2 | – | phosphorylation down-regulates | 17419683 | SIGNOR-154222 | |
| CSNK1A1 | GLI2 | – | phosphorylation down-regulates | 16611981 | SIGNOR-146112 | |
| GSK3B | GLI2 | Ser820 | VSSAYTVsRRSSGIS | phosphorylation down-regulates quantity by destabilization | 16611981 | SIGNOR-148472 |
| DYRK2 | GLI2 | – | phosphorylation down-regulates quantity by destabilization | 18455992 | SIGNOR-279034 | |
| CSNK1A1L | GLI2 | – | phosphorylation up-regulates | 16481469 | SIGNOR-144551 | |
| PRKACA | GLI2 | – | phosphorylation down-regulates | 16885213 | SIGNOR-148478 | |
| PRKACA | GLI2 | – | phosphorylation down-regulates | 17419683 | SIGNOR-154273 | |
| GSK3B | GLI2 | Ser863 | DPISTDAsRRSSEAS | phosphorylation down-regulates quantity by destabilization | 16611981 | SIGNOR-249590 |
| CSNK1A1L | GLI2 | – | phosphorylation up-regulates | 18698484 | SIGNOR-179972 | |
| GSK3B | GLI2 | Ser832 | GISPYFSsRRSSEAS | phosphorylation down-regulates quantity by destabilization | 16611981 | SIGNOR-249589 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | GLI2 PSer820 | phosphorylation down-regulates ⊣ | GLI2 | 16611981 | SIGNOR-148472 |
| GSK3B | phosphorylation up-regulates → | GLI2 PSer863 | phosphorylation down-regulates ⊣ | GLI2 | 16611981 | SIGNOR-249590 |
| GSK3B | phosphorylation up-regulates → | GLI2 PSer832 | phosphorylation down-regulates ⊣ | GLI2 | 16611981 | SIGNOR-249589 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-182573 |
| ULK3 | phosphorylation → up-regulates activity | GLI2 | SIGNOR-260798 |
| CSNK1A1 | phosphorylation down-regulates | GLI2 | SIGNOR-154222 |
| CSNK1A1 | phosphorylation down-regulates | GLI2 | SIGNOR-146112 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-148472 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-279034 |
| CSNK1A1L | phosphorylation → up-regulates | GLI2 | SIGNOR-144551 |
| PRKACA | phosphorylation down-regulates | GLI2 | SIGNOR-148478 |
| PRKACA | phosphorylation down-regulates | GLI2 | SIGNOR-154273 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-249590 |
| CSNK1A1L | phosphorylation → up-regulates | GLI2 | SIGNOR-179972 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-249589 |
