| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1L | GLI3 | – | phosphorylation up-regulates | 16481469 | SIGNOR-144554 | |
| PRKACA | GLI3 | Ser849 | NMLNRRDsSASTISS | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75343 |
| PRKACA | GLI3 | – | phosphorylation down-regulates | 17419683 | SIGNOR-154276 | |
| GSK3B | GLI3 | – | phosphorylation down-regulates quantity by destabilization | 11955435 | SIGNOR-219231 | |
| PRKACA | GLI3 | – | phosphorylation down-regulates | 10693759 | SIGNOR-75362 | |
| CSNK1A1 | GLI3 | – | phosphorylation down-regulates | 11955435 | SIGNOR-116512 | |
| PRKACA | GLI3 | Ser980 | VHAPRRCsDGGAHGY | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75359 |
| GSK3B | GLI3 | – | phosphorylation down-regulates quantity by destabilization | 16885213 | SIGNOR-148475 | |
| PRKACA | GLI3 | Ser865 | YLSSRRSsGISPCFS | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75347 |
| ULK3 | GLI3 | – | phosphorylation up-regulates activity | 19878745 | SIGNOR-260799 | |
| PRKACA | GLI3 | Ser1006 | GHGVRRAsDPVRTGS | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75339 |
| PRKACA | GLI3 | Ser877 | CFSSRRSsEASQAEG | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75351 |
| PRKACA | GLI3 | Ser907 | TDASRRSsEASQSDG | phosphorylation down-regulates quantity | 10693759 | SIGNOR-75355 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | GLI3 PSer849 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75343 |
| PRKACA | phosphorylation up-regulates → | GLI3 PSer980 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75359 |
| PRKACA | phosphorylation up-regulates → | GLI3 PSer865 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75347 |
| PRKACA | phosphorylation up-regulates → | GLI3 PSer1006 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75339 |
| PRKACA | phosphorylation up-regulates → | GLI3 PSer877 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75351 |
| PRKACA | phosphorylation up-regulates → | GLI3 PSer907 | phosphorylation down-regulates ⊣ | GLI3 | 10693759 | SIGNOR-75355 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1A1L | phosphorylation → up-regulates | GLI3 | SIGNOR-144554 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75343 |
| PRKACA | phosphorylation down-regulates | GLI3 | SIGNOR-154276 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | GLI3 | SIGNOR-219231 |
| PRKACA | phosphorylation down-regulates | GLI3 | SIGNOR-75362 |
| CSNK1A1 | phosphorylation down-regulates | GLI3 | SIGNOR-116512 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75359 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | GLI3 | SIGNOR-148475 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75347 |
| ULK3 | phosphorylation → up-regulates activity | GLI3 | SIGNOR-260799 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75339 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75351 |
| PRKACA | phosphorylation → down-regulates quantity | GLI3 | SIGNOR-75355 |
