| Name | AR |
| ID | P10275 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 669-900 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | AR | – | phosphorylation down-regulates activity | 21512132 | SIGNOR-280143 | |
| ERK1/2 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 18511414 | SIGNOR-244606 |
| SRC | AR | Tyr535 | MDSYSGPyGDMRLET | phosphorylation up-regulates activity | 20383201 | SIGNOR-278168 |
| CDK7 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-170599 |
| AKT | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates | 17470458 | SIGNOR-244140 |
| PIM1 | AR | – | phosphorylation up-regulates activity | 34697370 | SIGNOR-277575 | |
| PKN1 | AR | – | phosphorylation up-regulates | 17251915 | SIGNOR-152762 | |
| CDK1 | AR | Ser83 | QQQQQETsPRQQQQQ | phosphorylation up-regulates | 21799006 | SIGNOR-175692 |
| CDK9 | AR | Ser83 | QQQQQETsPRQQQQQ | phosphorylation up-regulates activity | 28062857 | SIGNOR-279456 |
| FER | AR | Tyr225 | PTSSKDNyLGGTSTI | phosphorylation up-regulates | 23906537 | SIGNOR-194749 |
| CyclinD3/CDK11B | AR | Ser310 | TEDTAEYsPFKGGYT | phosphorylation down-regulates quantity by destabilization | 17698582 | SIGNOR-273130 |
| TFIIH | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-269331 |
| CDK5 | AR | Ser83 | QQQQQETsPRQQQQQ | phosphorylation up-regulates | 21799006 | SIGNOR-175696 |
| AKT1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates | 17470458 | SIGNOR-154631 |
| EPHA3 | AR | Tyr535 | MDSYSGPyGDMRLET | phosphorylation up-regulates activity | 20570899 | SIGNOR-279370 |
| CyclinD3/CDK11A | AR | Ser310 | TEDTAEYsPFKGGYT | phosphorylation down-regulates quantity by destabilization | 17698582 | SIGNOR-273125 |
| AKT | AR | Ser792 | CVRMRHLsQEFGWLQ | phosphorylation down-regulates activity | 11404460 | SIGNOR-244136 |
| PP2Ca_R1A_Bd | AR | Ser83 | QQQQQETsPRQQQQQ | dephosphorylation down-regulates activity | 27858941 | SIGNOR-254759 |
| PIM1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates activity | 22986532 | SIGNOR-278177 |
| GSK3B | AR | – | phosphorylation down-regulates activity | 14985354 | SIGNOR-279334 | |
| MAPK1 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 18511414 | SIGNOR-178718 |
| TNK2 | AR | Tyr365 | AYQSRDYyNFPLALA | phosphorylation up-regulates activity | 25950519 | SIGNOR-278195 |
| AKT1 | AR | Ser792 | CVRMRHLsQEFGWLQ | phosphorylation down-regulates activity | 11404460 | SIGNOR-108508 |
| EPHA3 | AR | Tyr552 | DHVLPIDyYFPPQKT | phosphorylation up-regulates activity | 20570899 | SIGNOR-279371 |
| PAK6 | AR | Ser579 | YGALTCGsCKVFFKR | phosphorylation down-regulates quantity by destabilization | 23132866 | SIGNOR-279247 |
| TNK2 | AR | Tyr269 | QLRGDCMyAPLLGVP | phosphorylation up-regulates activity | 20383201 | SIGNOR-278194 |
| AKT1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates activity | 11404460 | SIGNOR-108504 |
| PTEN | AR | Ser83 | QQQQQETsPRQQQQQ | dephosphorylation up-regulates activity | 24480624 | SIGNOR-277077 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 18511414 | SIGNOR-244606 |
| SRC | phosphorylation up-regulates → | AR PTyr535 | phosphorylation up-regulates → | AR | 20383201 | SIGNOR-278168 |
| CDK7 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-170599 |
| AKT | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 17470458 | SIGNOR-244140 |
| CDK1 | phosphorylation up-regulates → | AR PSer83 | phosphorylation up-regulates → | AR | 21799006 | SIGNOR-175692 |
| CDK9 | phosphorylation up-regulates → | AR PSer83 | phosphorylation up-regulates → | AR | 28062857 | SIGNOR-279456 |
| FER | phosphorylation up-regulates → | AR PTyr225 | phosphorylation up-regulates → | AR | 23906537 | SIGNOR-194749 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | AR PSer310 | phosphorylation down-regulates ⊣ | AR | 17698582 | SIGNOR-273130 |
| TFIIH | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-269331 |
| CDK5 | phosphorylation up-regulates → | AR PSer83 | phosphorylation up-regulates → | AR | 21799006 | SIGNOR-175696 |
| AKT1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 17470458 | SIGNOR-154631 |
| EPHA3 | phosphorylation up-regulates → | AR PTyr535 | phosphorylation up-regulates → | AR | 20570899 | SIGNOR-279370 |
| CyclinD3/CDK11A | phosphorylation up-regulates → | AR PSer310 | phosphorylation down-regulates ⊣ | AR | 17698582 | SIGNOR-273125 |
| AKT | phosphorylation up-regulates → | AR PSer792 | phosphorylation down-regulates ⊣ | AR | 11404460 | SIGNOR-244136 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | AR PSer83 | dephosphorylation up-regulates → | AR | 27858941 | SIGNOR-254759 |
| PIM1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 22986532 | SIGNOR-278177 |
| MAPK1 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 18511414 | SIGNOR-178718 |
| TNK2 | phosphorylation up-regulates → | AR PTyr365 | phosphorylation up-regulates → | AR | 25950519 | SIGNOR-278195 |
| AKT1 | phosphorylation up-regulates → | AR PSer792 | phosphorylation down-regulates ⊣ | AR | 11404460 | SIGNOR-108508 |
| EPHA3 | phosphorylation up-regulates → | AR PTyr552 | phosphorylation up-regulates → | AR | 20570899 | SIGNOR-279371 |
| PAK6 | phosphorylation up-regulates → | AR PSer579 | phosphorylation down-regulates ⊣ | AR | 23132866 | SIGNOR-279247 |
| TNK2 | phosphorylation up-regulates → | AR PTyr269 | phosphorylation up-regulates → | AR | 20383201 | SIGNOR-278194 |
| AKT1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 11404460 | SIGNOR-108504 |
| PTEN | dephosphorylation down-regulates ⊣ | AR PSer83 | dephosphorylation down-regulates ⊣ | AR | 24480624 | SIGNOR-277077 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → down-regulates activity | AR | SIGNOR-280143 |
| ERK1/2 | phosphorylation down-regulates | AR | SIGNOR-244606 |
| SRC | phosphorylation → up-regulates activity | AR | SIGNOR-278168 |
| CDK7 | phosphorylation down-regulates | AR | SIGNOR-170599 |
| AKT | phosphorylation down-regulates | AR | SIGNOR-244140 |
| PIM1 | phosphorylation → up-regulates activity | AR | SIGNOR-277575 |
| PKN1 | phosphorylation → up-regulates | AR | SIGNOR-152762 |
| CDK1 | phosphorylation → up-regulates | AR | SIGNOR-175692 |
| CDK9 | phosphorylation → up-regulates activity | AR | SIGNOR-279456 |
| FER | phosphorylation → up-regulates | AR | SIGNOR-194749 |
| CyclinD3/CDK11B | phosphorylation down-regulates quantity by destabilization | AR | SIGNOR-273130 |
| TFIIH | phosphorylation down-regulates | AR | SIGNOR-269331 |
| CDK5 | phosphorylation → up-regulates | AR | SIGNOR-175696 |
| AKT1 | phosphorylation down-regulates | AR | SIGNOR-154631 |
| EPHA3 | phosphorylation → up-regulates activity | AR | SIGNOR-279370 |
| CyclinD3/CDK11A | phosphorylation down-regulates quantity by destabilization | AR | SIGNOR-273125 |
| AKT | phosphorylation → down-regulates activity | AR | SIGNOR-244136 |
| PP2Ca_R1A_Bd | dephosphorylation → down-regulates activity | AR | SIGNOR-254759 |
| PIM1 | phosphorylation → down-regulates activity | AR | SIGNOR-278177 |
| GSK3B | phosphorylation → down-regulates activity | AR | SIGNOR-279334 |
| MAPK1 | phosphorylation down-regulates | AR | SIGNOR-178718 |
| TNK2 | phosphorylation → up-regulates activity | AR | SIGNOR-278195 |
| AKT1 | phosphorylation → down-regulates activity | AR | SIGNOR-108508 |
| EPHA3 | phosphorylation → up-regulates activity | AR | SIGNOR-279371 |
| PAK6 | phosphorylation down-regulates quantity by destabilization | AR | SIGNOR-279247 |
| TNK2 | phosphorylation → up-regulates activity | AR | SIGNOR-278194 |
| AKT1 | phosphorylation → down-regulates activity | AR | SIGNOR-108504 |
| PTEN | dephosphorylation → up-regulates activity | AR | SIGNOR-277077 |