| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates activity | 22986532 | SIGNOR-278177 |
| AKT | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates | 17470458 | SIGNOR-244140 |
| AKT1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates | 17470458 | SIGNOR-154631 |
| AKT1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates activity | 11404460 | SIGNOR-108504 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 22986532 | SIGNOR-278177 |
| AKT | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 17470458 | SIGNOR-244140 |
| AKT1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 17470458 | SIGNOR-154631 |
| AKT1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 11404460 | SIGNOR-108504 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → down-regulates activity | AR | SIGNOR-278177 |
| AKT | phosphorylation down-regulates | AR | SIGNOR-244140 |
| AKT1 | phosphorylation down-regulates | AR | SIGNOR-154631 |
| AKT1 | phosphorylation → down-regulates activity | AR | SIGNOR-108504 |
