Entity Details

Name CDK7_Ser516
ID P10275
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK7ARSer516VSRVPYPsPTCVKSEphosphorylation
down-regulates		21157430SIGNOR-170599
MAPK1ARSer516VSRVPYPsPTCVKSEphosphorylation
down-regulates		18511414SIGNOR-178718
TFIIHARSer516VSRVPYPsPTCVKSEphosphorylation
down-regulates		21157430SIGNOR-269331
ERK1/2ARSer516VSRVPYPsPTCVKSEphosphorylation
down-regulates		18511414SIGNOR-244606
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK7phosphorylation
up-regulates
→
AR
PSer516		phosphorylation
down-regulates
⊣		AR21157430SIGNOR-170599
MAPK1phosphorylation
up-regulates
→
AR
PSer516		phosphorylation
down-regulates
⊣		AR18511414SIGNOR-178718
TFIIHphosphorylation
up-regulates
→
AR
PSer516		phosphorylation
down-regulates
⊣		AR21157430SIGNOR-269331
ERK1/2phosphorylation
up-regulates
→
AR
PSer516		phosphorylation
down-regulates
⊣		AR18511414SIGNOR-244606
Regulator Mechanism/Effect Target SIGNOR-ID
CDK7phosphorylation
img/direct_inhibition.png
down-regulates 		ARSIGNOR-170599
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates 		ARSIGNOR-178718
TFIIHphosphorylation
img/direct_inhibition.png
down-regulates 		ARSIGNOR-269331
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates 		ARSIGNOR-244606