| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TFIIH | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-269331 |
| CDK7 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 21157430 | SIGNOR-170599 |
| ERK1/2 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 18511414 | SIGNOR-244606 |
| MAPK1 | AR | Ser516 | VSRVPYPsPTCVKSE | phosphorylation down-regulates | 18511414 | SIGNOR-178718 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TFIIH | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-269331 |
| CDK7 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 21157430 | SIGNOR-170599 |
| ERK1/2 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 18511414 | SIGNOR-244606 |
| MAPK1 | phosphorylation up-regulates → | AR PSer516 | phosphorylation down-regulates ⊣ | AR | 18511414 | SIGNOR-178718 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TFIIH | phosphorylation down-regulates | AR | SIGNOR-269331 |
| CDK7 | phosphorylation down-regulates | AR | SIGNOR-170599 |
| ERK1/2 | phosphorylation down-regulates | AR | SIGNOR-244606 |
| MAPK1 | phosphorylation down-regulates | AR | SIGNOR-178718 |
