Entity Details

Name ARAF
ID P10398
Role kinase
Enzymatic Domains
RBD 19-91
PROSITE-ProRule
Protein kinase 310-570
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ARAFMAP2K2–phosphorylation
up-regulates		21779497SIGNOR-175142
ARAFMAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates		8621729SIGNOR-236451
ARAFMAP2K1Ser222LIDSMANsFVGTRSYphosphorylation
up-regulates		8621729SIGNOR-235944
ARAFSLC9A3R2Ser303QESGLHLsPTAAEAKphosphorylation
up-regulates activity		26310448SIGNOR-273503
ARAFSMAD2–phosphorylation
down-regulates quantity by destabilization		23591895SIGNOR-279391
ARAFMEK1/2–phosphorylation
up-regulates		21779497SIGNOR-244809
ARAFMEK1/2–phosphorylation
up-regulates		8621729SIGNOR-244813
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ARAFphosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K18621729SIGNOR-236451
ARAFphosphorylation
up-regulates
→
MAP2K1
PSer222		phosphorylation
up-regulates
→		MAP2K18621729SIGNOR-235944
ARAFphosphorylation
up-regulates
→
SLC9A3R2
PSer303		phosphorylation
up-regulates
→		SLC9A3R226310448SIGNOR-273503
Regulator Mechanism/Effect Target SIGNOR-ID
ARAFphosphorylation
→
up-regulates 		MAP2K2SIGNOR-175142
ARAFphosphorylation
→
up-regulates 		MAP2K1SIGNOR-236451
ARAFphosphorylation
→
up-regulates 		MAP2K1SIGNOR-235944
ARAFphosphorylation
→
up-regulates activity 		SLC9A3R2SIGNOR-273503
ARAFphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SMAD2SIGNOR-279391
ARAFphosphorylation
→
up-regulates 		MEK1/2SIGNOR-244809
ARAFphosphorylation
→
up-regulates 		MEK1/2SIGNOR-244813