| Name | H1-4 |
| ID | P10412 |
| Role | substrate |
| Enzymatic Domains |
H15 36-109 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | H1-4 | Ser187 | KPKKAPKsPAKAKAV | phosphorylation down-regulates activity | 28539972 | SIGNOR-279691 |
| AURKB | H1-4 | Ser27 | VKKKARKsAGAAKRK | phosphorylation up-regulates quantity by stabilization | 21511733 | SIGNOR-262658 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK9 | phosphorylation up-regulates → | H1-4 PSer187 | phosphorylation down-regulates ⊣ | H1-4 | 28539972 | SIGNOR-279691 |
| AURKB | phosphorylation up-regulates → | H1-4 PSer27 | phosphorylation up-regulates → | H1-4 | 21511733 | SIGNOR-262658 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK9 | phosphorylation → down-regulates activity | H1-4 | SIGNOR-279691 |
| AURKB | phosphorylation → up-regulates quantity by stabilization | H1-4 | SIGNOR-262658 |